Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

    August 2019 in “ Research Square (Research Square) ”
    Mei Jin, Qin Feng Zhao, Ping Ni, Jinhua Piao, Ai Jing Piao
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    TLDR Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.
    The document presents a study on the role of long non-coding RNAs (LncRNAs) in the development of hair follicles and villus growth in Liaoning cashmere goats, with a focus on the effects of Fibroblast Growth Factor 5 (FGF5) treatment. The researchers identified two LncRNAs, XLOC_011424 and XLOC_011157, that were significantly affected by FGF5. They found that overexpression of LncRNA XLOC_011424 (LncRNA1) increased the expression of target genes involved in amino acid metabolism and keratin production, which are important for hair growth. The study used RNA-seq sequencing, qPCR, fluorescence in situ hybridization (FISH), and lentiviral interference techniques to demonstrate that LncRNA1 and its target genes are regulated by FGF5, which in turn affects hair follicle development and villus growth. This research provides a theoretical foundation for molecular-assisted breeding of Liaoning cashmere goats. However, the document does not specify the number of animals or samples used, which is crucial for evaluating the study's robustness.
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