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Glossary RNA sequencing

technology to analyze gene expression by examining RNA transcripts

RNA sequencing, often abbreviated as RNA-seq, is a technology that allows scientists to study the complete set of RNA transcripts produced by the genome under specific circumstances or in a specific cell. This method provides insights into gene expression patterns, helping researchers understand how genes are turned on or off in different conditions, which is crucial for studying diseases like alopecia and other biological processes.

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research Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq)

39 citations , January 2020 in “Scientific Reports”

This study identified four circRNAs with significantly different expression levels in Liaoning cashmere goats, suggesting a potential role in regulating cashmere fineness.

research Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases

17 citations , October 2021 in “Cellular & Molecular Biology Letters”

This study identified novel biomarkers through gene expression differences between keratinocytes and fibroblasts in newborn mice, which may aid in developing therapies for skin conditions.

research 583 RNA sequencing of immortalised balding and non balding DPCs identifies potential balding gene signatures

November 2022 in “Journal of Investigative Dermatology”

This study found that non-balding dermal papilla cells emphasized extracellular matrix organization and reduced inflammation when cultured in 3D or with adipose-derived stem cells, unlike balding cells which maintained inflammatory pathways.

research Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus

9 citations , February 2022 in “BMC Genomics”

This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.

research Investigating RNA-Seq-based differential gene expression during hair follicle development in Angora goat skin

August 2024 in “Journal of Animal Science and Technology”

This study identified specific keratin-associated protein genes that are highly expressed in different varieties and sexes of Angora goats, providing insights for improving mohair development through targeted breeding strategies.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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