Comprehensive RNA Sequencing in Primary Murine Keratinocytes and Fibroblasts Identifies Novel Biomarkers and Provides Potential Therapeutic Targets for Skin-Related Diseases

    October 2021 in “ Cellular & Molecular Biology Letters ”
    Tiancheng Wang, Zhenwei Zhou, Enjing Luo … Baojin Yao
    Studysummary This study identified novel biomarkers through gene expression differences between keratinocytes and fibroblasts in newborn mice, which may aid in developing therapies for skin conditions.
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    Research cited in this study 5

    1. Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense Journal of Investigative Dermatology · 2019
    2. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    3. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017
    4. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    5. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008