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GlossarySanger sequencing

determines DNA sequence by incorporating chain-terminating nucleotides during replication

Sanger sequencing, also known as chain termination sequencing, is a method used to determine the precise order of nucleotides in a DNA molecule. It involves copying the DNA in a way that incorporates special molecules called dideoxynucleotides, which stop the copying process at specific points, allowing scientists to piece together the sequence by analyzing the resulting fragments. This technique has been fundamental in genetic research and diagnostics.

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research Identification of a Recurrent Nonsense Mutation in HR Gene Responsible for Atrichia with Papular Lesions in Two Kashmiri Families

3 citations , February 2020 in “The journal of gene medicine”

A mutation in the HR gene causes a rare form of irreversible hair loss in two Kashmiri families. Whole exome sequencing is effective for finding such mutations.

Mutational Spectrum in 101 Patients with Hypohidrotic Ectodermal Dysplasia and Breakpoint Mapping in Independent Cases of Rare Genomic Rearrangements

research Mutational Spectrum in 101 Patients with Hypohidrotic Ectodermal Dysplasia and Breakpoint Mapping in Independent Cases of Rare Genomic Rearrangements

30 citations , June 2016 in “Journal of Human Genetics”

Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.

A Disease-Causing Novel Missense Mutation in the ST14 Gene Underlies Autosomal Recessive Ichthyosis with Hypotrichosis Syndrome in a Consanguineous Family

research A Disease-Causing Novel Missense Mutation in the ST14 Gene Underlies Autosomal Recessive Ichthyosis with Hypotrichosis Syndrome in a Consanguineous Family

9 citations , March 2018 in “European journal of dermatology/EJD. European journal of dermatology”

A new mutation in the ST14 gene causes a rare skin and hair disorder in a specific family.

research Hereditary Vitamin D-Resistant Rickets in Lebanese Patients: The p.R391S and p.H397P Variants Have Different Phenotypes

4 citations , January 2017 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

Two different mutations in the vitamin D receptor gene cause different symptoms and responses to treatment in Lebanese patients with hereditary rickets.

research Keratin 17-Related Recessive Atypical Pachyonychia Congenita with Variable Hair and Tooth Anomalies

3 citations , June 2022 in “European journal of human genetics”

A new type of pachyonychia congenita linked to a specific keratin gene mutation was found in two Pakistani families.

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community My on going battle with male pattern baldness M(18) Topical Fin, Topical Min 9 months

in Progress Pictures 1015 upvotes 8 months ago

A user shared their positive experience using topical finasteride and minoxidil for nine months to combat male pattern baldness, reporting healthier and thicker hair without side effects. They recommend these treatments but advise researching potential side effects and consulting a professional.

community An idea that I came up with recently💡

in Satire 289 upvotes 2 years ago

User suggests rotating scalp 180 degrees to address hair loss. Others discuss sanity, ethics, and similar procedures like scalp reduction and hair transplants.

community Justin Bieber got a hair transplant

in Transplants 1481 upvotes 3 months ago

Justin Bieber has had multiple hair transplants, with discussions on the cost and quality in places like Turkey. Despite using treatments like finasteride, his hairline appears unnatural to some.

community Fin journey update, 4 years, 1mg oral daily

in Progress Pictures 387 upvotes 6 months ago

The user has been using 1mg oral finasteride daily for four years, experiencing significant hair regrowth and increased testosterone levels without negative side effects. They advise patience and monitoring for side effects, noting that their hair continues to improve with this treatment.

community Great work done by the doctor (Hair transplant) Toronto Canada

in Progress Pictures 509 upvotes 1 year ago

A user shared progress pictures of a hair transplant done in Toronto, Canada. The conversation includes comments on the appearance of Antonio Conte, with some suggesting he looked better after shaving his head.

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