7 citations
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August 2020 in “Majalah Farmasetika” This review concluded that a herbal hair tonic formulated with 2.5% green tea leaf extract, in combination with specific solvents and additives, showed the best properties for stimulating hair growth.
5 citations
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September 2019 in “Medical Sains Jurnal Ilmiah Kefarmasian” This research investigates the potential of green tea leaves and herb gotukola for promoting hair growth, but it reports no new experimental results.
2 citations
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February 2021 in “IOP Conference Series Earth and Environmental Science” This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.
1 citations
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November 2020 in “UMM Institutional Repository (University of Maine at Machias)” In this true experimental study, researchers assessed the antibacterial effect of white jasmine leaf extract against Propionibacterium acnes and found varying inhibition zone diameters, with 500 µg/mL achieving up to 10.95 mm, though less effective than clindamycin, which reached 28.55 mm.
April 2025 in “Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat” This study found that variations in propylene glycol concentration in wax apple leaf extract hair tonic affected pH, specific gravity, and viscosity, aligning with SNI requirements.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, Platycladus orientalis leaf extract loaded into hyaluronic acid microneedles was found to promote hair follicle growth by enhancing the environment for hair cell proliferation and activating repair pathways, suggesting potential as a treatment for androgenic alopecia.
June 2021 in “Journal of Pharmaceutical Care Anwar Medika” This study investigated the physical stability of hair tonic formulations made from ethanol extract of cayenne pepper leaves, finding that formulations with specific concentrations of propylene glycol and ethanol had good physical stability.
July 2019 in “Majalah Obat Tradisional” This study reported that a 4% water fraction of green tea leaf extract showed the most effective hair growth promotion in rabbits.
February 2015 in “Jurnal e-Biomedik” This study found that aloe vera extract accelerated wound healing in incised rabbit skin.
1 citations
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September 2025 in “Molecules” This study comparatively evaluated different extraction techniques for Schinus terebinthifolius Raddi leaf extracts and found that conventional extraction with ethanol yielded the highest antioxidant activity and beneficial effects on skin cell viability, supporting its potential use in sustainable cosmeceutical formulations targeting skin aging.
September 2024 in “International Journal of Molecular Sciences” This study found that hot water extract of Hydrangea serrata leaf and hydrangenol promoted hair growth by enhancing 5α-reductase inhibitory activity, stimulating dermal papilla cell growth, and exhibiting anti-inflammatory and anti-androgenic effects in cell cultures, mice, and human skin organoid models.
June 2024 in “Deleted Journal” This study explored the effects of hair tonics made from a combination of kelor leaf and fragrant pandan leaf ethanol extracts on rat hair growth, finding that these combinations influenced hair growth when compared to single extract formulations over 28 days.
December 2024 in “Tropical Journal of Natural Product Research” This study evaluated the anti-alopecia effects of Petroselinum crispum leaf extracts in a rabbit model and through molecular docking analysis, finding that two ethyl acetate fractions promoted hair growth, with effects comparable to minoxidil, suggesting potential for alopecia treatment development.
44 citations
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January 2007 in “Biological & pharmaceutical bulletin” This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.
4 citations
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August 2017 in “Cosmetics” This study observed that Biota orientalis L. leaf extract may promote hair growth and suppress sebum production in human cells, suggesting potential benefits for hair restoration.
1 citations
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June 2025 in “Biomolecules” This study found that extracts from Stauntonia hexaphylla leaves and fruits, particularly those with a higher leaf-to-fruit ratio, significantly enhanced osteogenic activity and inhibited osteoclast-related gene expression in vitro, suggesting potential for osteoporosis prevention.
December 2024 in “Jurnal Mandala Pharmacon Indonesia” In this study, high-dose oral administration of Ramania leaf ethanol extract in Wistar rats resulted in no significant acute toxicity symptoms, though gastric ulcers and hair loss were observed. The extract is classified as non-toxic under specified guidelines, with an LD50 greater than 5000 mg/kg.
January 2022 in “JPK Jurnal Proteksi Kesehatan” This study found that the ethanol extract of mangkokan leaf (Polyscias scutellarium) demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, with higher concentrations showing greater inhibition zones, particularly against Staphylococcus aureus.
This study tested a natural hair dye made from papaya seed extract, celery leaf, and avocado, finding color change in animal hair but also noting tissue changes like hyperkeratosis.
17 citations
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August 2010 in “International Journal of Cosmetic Science” This study found that a cosmetic formula containing 2% Orthosiphon stamineus leaf extract significantly reduced skin oiliness and pore size, showing better results than a formula with 1% zinc gluconate.
5 citations
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December 2020 in “Materials Research Express” This study found that silver nanoparticles biofabricated using Ostericum koreanum leaf extract inhibited inflammatory cytokine production in stimulated human mast cell lines, suggesting potential use in treating mast cell-mediated allergic diseases.
February 2026 in “Inflammopharmacology” This study found that a 25% Pistacia atlantica leaf extract ointment significantly enhanced wound healing in rats, performing comparably to phenytoin in terms of epithelialization, angiogenesis, and collagen deposition, with reduced inflammation, suggesting it may be a safe and effective alternative for wound management.
May 2024 in “Pharmacia/Farmaciâ” In this study, Ipomoea batatas leaf extracts exhibited significant hair growth stimulation and strong antifungal activity against Malassezia furfur, potentially offering a promising treatment for alopecia with further research needed on their androgen receptor inhibition potential.
June 2023 in “jurnal veteriner” In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects.
January 2012 in “Journal of Natural Remedies” This study found that the aqueous extract of Abrus precatorius leaf promoted hair growth in experimental settings, with effects comparable to 2% minoxidil.
January 2024 in “Journal of Biosciences and Medicines” In this study, combining Ginkgo biloba extract dropping pills with butylphthalide capsules improved cognitive and neurological function, daily living activities, and reduced inflammatory responses in patients with cognitive dysfunction following an acute ischemic stroke, compared to butylphthalide treatment alone.
January 2014 in “UMS Institutional Repository (Universiti Malaysia Sabah)” This study found that Murraya koenigii extracts and compounds demonstrated potent antibacterial and cytotoxic activities, with notable effects against antibiotic-resistant strains and cancer cell lines, supporting its potential for further pharmacological investigation.
45 citations
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January 2016 in “Journal of Nanomaterials” In this study, silver nanoparticles derived from Ziziphus nummularia leaf extract showed enhanced antibacterial, antifungal, antioxidant, and hair growth properties compared to the leaf extract itself.
November 2021 in “Veterinary world/Veterinary World” In this study, dogs with localized demodicosis showed notable improvement in dermatological lesions when treated with Dipterocarpus alatus oil combined with Rhinacanthus nasutus leaf extract, particularly by day 28 of post-treatment, with no observed allergic reactions or clinical signs.
10 citations
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January 2022 in “Journal of Research in Pharmacy” In this experimental study on Wistar albino rats, Cotinus coggygria leaf extract demonstrated potential as a treatment for burn-induced skin damage by reducing cytokine levels and promoting tissue healing.