Antitumor Activities of Typhonium Flagelliforme Extract Combined with Natural Interferons of Canine and Feline in Mice with DMBA-Induced Skin Tumors

    June 2023 in “ jurnal veteriner ”
    Eva Harlina, Ardi Sandriya, Riski Rostantinata, Waras Nurcholis, Lina Noviyanti Sutardi, Mawar Subangkit, Rachmi Ridho, Bambang Pontjo Priosoeryanto
    TLDR The combination of Typhonium flagelliforme extract and natural interferons effectively reduces tumor growth in mice.
    This study investigated the antitumor effects of Typhonium flagelliforme leaf-ethanolic extract combined with natural interferons from canines or felines in 18 female mice with DMBA-induced skin tumors. The combination therapy was found to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and the expression of PCNA and Caspase-3. The study observed three types of tumors: anaplastic carcinoma, fibrosarcoma, and squamous cell carcinoma, with alopecia and reddish skin in tumor-bearing mice. The results suggest that the combination therapy has significant antitumor activity compared to single treatments.
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