Antitumor Activities of Typhonium Flagelliforme Extract Combined with Natural Interferons of Canine and Feline in Mice with DMBA-Induced Skin Tumors

    June 2023 in “ jurnal veteriner ”
    Eva Harlina, Ardi Sandriya, Riski Rostantinata, Waras Nurcholis, Lina Noviyanti Sutardi, Mawar Subangkit, Rachmi Ridho, Bambang Pontjo Priosoeryanto
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    Studysummary In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects. Our plain-language summary of this paper — not a Tressless recommendation.
    This study investigated the antitumor effects of Typhonium flagelliforme leaf-ethanolic extract combined with natural interferons from canines or felines in 18 female mice with DMBA-induced skin tumors. The combination therapy was found to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and the expression of PCNA and Caspase-3. The study observed three types of tumors: anaplastic carcinoma, fibrosarcoma, and squamous cell carcinoma, with alopecia and reddish skin in tumor-bearing mice. The results suggest that the combination therapy has significant antitumor activity compared to single treatments.
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