Comparative Study on Antioxidant Potential of Schinus Terebinthifolius Extracts Prepared by Conventional Extraction, Accelerated Solvent Extraction, and Pulsed Electric Field Method

    September 2025 in “ Molecules ”
    Tanakarn Chaithep, Anurak Muangsanguan, Juan Manuel Castagnini, Francisco J. Martí-Quijal, Korawan Sringarm, Chaiwat Arjin, Pornchai Rachtanapun, Francisco J. Barba, Warintorn Ruksiriwanich
    TLDR The conventional extraction method with 50% ethanol was the most effective for antioxidant activity.
    This study assessed the antioxidant potential of Schinus terebinthifolius extracts using three extraction methods: conventional extraction (CE), accelerated solvent extraction (ASE), and pulsed electric field (PEF) extraction. The CE method with 50% ethanol for 120 minutes (C-4) was the most effective, yielding the highest phenolic and flavonoid content and demonstrating strong antioxidant activity. The C-4 extract significantly improved cell viability and upregulated antioxidant genes in H2O2-induced HaCaT keratinocytes, suggesting its potential as a sustainable ingredient for cosmeceuticals targeting oxidative stress-related skin aging. The study emphasizes the effectiveness of CE in maximizing bioactive compound recovery, outperforming ASE and PEF methods. Future research should focus on isolating active compounds and understanding their molecular mechanisms.
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