Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that in HIV-infected men, erectile dysfunction was influenced by the duration of HIV infection but not associated with serum testosterone or HAART therapy.

The researchers reported that epitestosterone treatment reduced eicosanoid levels generated by cyclooxygenases and lipoxygenases in rabbit liver samples with carrageenan-induced inflammation.

This study suggests that epithelial-derived Pop-Up Keratinocytes (ePUKs) may be a promising cell source for regenerative medicine due to their specific phenotypic traits and their influence on wound healing.

This study presents a new LC-MS/MS method that allows for more accurate detection of seven steroid hormones in human hair, enhancing the specificity and reliability of hormone analysis in psychoneuroendocrinological research.

This study successfully applied an optimized LC-MS/MS method for accurately determining finasteride concentrations and assessing its pharmacokinetics in healthy volunteers.

This study developed analytical methods to better understand hair treatment with cosmetic formulations, revealing that active agents primarily adsorb on the hair surface during short washes.

This study developed a new measurement procedure using isotope dilution-liquid chromatography-tandem mass spectrometry for accurate quantification of DHEAS in human serum or plasma, demonstrating high selectivity, sensitivity, and low measurement uncertainty, making it suitable for routine standardization and clinical evaluation.

This study reported that analyzing hair cortisol levels using a validated online SPE LC-MS method provided a way to assess long-term hormone secretion in 114 healthy volunteers, with a median hair cortisol value of 4.76 pg/mg.

This study describes a fast LC/MS/MS method for detecting various synthetic drugs in urine, meeting World Anti-Doping Agency performance limits.

This study developed and validated a sensitive LC-MS/MS method for quantifying tamsulosin in human serum, achieving high analyte recovery and demonstrating applicability in clinical research for benign prostatic hyperplasia.

This commentary discusses the challenges of matrix effects in LC–MS analysis and introduces the concept of a matrix effect factor using stable isotopically labeled internal standards to improve analysis reliability.

In this study, researchers developed a sensitive LC–MS–MS assay to measure 3α-androstanediol levels in rat plasma and observed that testosterone raises these levels via a 5α-reductase pathway.

This study validated a highly selective and fast LC–MS/MS method for accurately measuring levels of tadalafil and finasteride in human plasma, adhering to international bioanalytical guidelines.

This study found that improving the solubility of wogonin can significantly enhance its bioavailability in Beagle dogs.

This study developed a novel method to simultaneously measure finasteride, dutasteride, and related biomarkers in serum, finding that both drugs lowered DHT levels while increasing substrate concentrations.

This study developed and validated a mass spectrometric method to measure hydroxy-androgens in serum, which aids in understanding androgen synthesis in castration resistant prostate cancer.

This study suggests that Keratin 6hf may be a potential marker of oral squamous cell carcinoma and could play a role in its progression, though further research is needed to understand its function.

This study developed and validated a high-resolution mass spectrometry method to screen for prohibited substances and analyze six endogenous steroids in urine according to World Antidoping Agency requirements, demonstrating its effectiveness for antidoping analysis.

In this study, researchers identified several active metabolites in Eclipta alba, demonstrated strong interaction with Alzheimer's disease proteins, and found that 28 days of treatment improved memory without significant toxicity in rats, suggesting potential pathways for treating Alzheimer's.

In this study, the researchers compared the pharmacokinetics and tissue distribution of dihydroartemisinin in nanostructured lipid carriers versus in solution, finding longer mean residence times and variable organ accumulation with the nanostructured lipid carriers.

This study developed methods for detecting carboxy-finasteride in urine for doping control, demonstrating detection up to 49 hours post-administration with high precision and accuracy.

This study investigated the gene and protein expression differences in early and late feathering chickens, identifying several pathways, like JAK-STAT and WNT, potentially involved in non-Mendelian feather growth regulation.

Rosemary extracts, specifically compounds like rosmarinic acid and carnosic acid, can protect hair from UV damage.

This study observed that vimentin and transthyretin proteins were more highly expressed in black sheep skins compared to white, suggesting their involvement in coat color formation.

This study identified 18 significant metabolites and two enriched metabolic pathways, necroptosis and ABC transporters, in serum samples of acne patients with and without insulin resistance, potentially aiding in the clinical diagnosis and drug development for these patients.

This study suggests that epithelial-derived pop-up keratinocytes (ePUKs) may improve regenerative medicine applications due to their specific phenotype and increased expression of proteins involved in regulating cellular movement and wound healing.

This study analyzed Sphenodesme involucrata var. paniculata leaves and found high carbohydrate and calcium content, along with several bioactive compounds, supporting their use in traditional medicine for their nutrient-rich properties.

This study found that total testosterone and free testosterone are recommended as first-line tests for diagnosing biochemical hyperandrogenism in women with PCOS; liquid chromatography with tandem mass spectrometry is preferred for its accuracy.

This study describes a validated UPLC-MS/MS method for quantifying finasteride in human plasma, demonstrating higher specificity, improved resolution, increased sensitivity, and faster analysis times compared to conventional HPLC-MS/MS methods.

Lacto-fermentation changes amino acid profiles in bovine colostrum, but results are inconsistent.