Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism

    April 2016 in “ Annals of laboratory medicine ”
    Su Hyeon Lee, Eung Ju Kim, Dong Hyoung Lee … Man Ho Choi
    Studysummary The researchers reported that epitestosterone treatment reduced eicosanoid levels generated by cyclooxygenases and lipoxygenases in rabbit liver samples with carrageenan-induced inflammation.
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    Research cited in this study 4

    1. Comparative GC-MS Based In Vitro Assays of 5α-Reductase Activity Using Rat Liver S9 Fraction Mass spectrometry letters · 2012
    2. The Role of Inflammation and Immunity in the Pathogenesis of Androgenetic Alopecia PubMed · 2011
    3. Biochemical Roles of Testosterone and Epitestosterone to 5α-Reductase as Indicators of Male-Pattern Baldness Journal of Investigative Dermatology · 2001
    4. Epitestosterone—An Endogenous Antiandrogen? Journal of steroid biochemistry/Journal of Steroid Biochemistry · 1989