Evaluating the Diagnostic Accuracy of Androgen Measurement in Polycystic Ovary Syndrome: A Systematic Review and Diagnostic Meta-Analysis to Inform Evidence-Based Guidelines

September 2024 in “ Human Reproduction Update ”

Asmamaw Demis, Anju E. Joham, Helena Teede, Aya Mousa, Arul Earnest, James Hawley, Laura G. E. Smith, Ricardo Azziz, Wiebke Arlt, Chau Thien Tay

androgen measurement polycystic ovary syndrome PCOS diagnostic accuracy assay method standardized diagnostic criteria

TLDR Androgen measurement helps diagnose PCOS, but accuracy varies, needing standard methods.

This systematic review and diagnostic meta-analysis aimed to evaluate the diagnostic accuracy of androgen measurement in diagnosing polycystic ovary syndrome (PCOS). The study synthesized data from multiple sources to inform evidence-based guidelines. The findings suggest that while androgen measurement is a useful tool in diagnosing PCOS, there are variations in accuracy depending on the specific androgen measured and the assay method used. The study emphasizes the need for standardized diagnostic criteria and methods to improve the reliability of PCOS diagnosis. This research is crucial for developing more accurate and consistent guidelines for diagnosing PCOS, ultimately aiding in better patient management and treatment outcomes.

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Research cited in this study

15 / 15 results

Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

8 citations , August 2023 in “The Journal of Clinical Endocrinology and Metabolism”

Follow the latest international guidelines to assess and manage Polycystic Ovary Syndrome effectively.

research Hyperandrogenism in Polycystic Ovarian Syndrome and Role of CYP Gene Variants: A Review

49 citations , November 2019 in “Egyptian Journal of Medical Human Genetics”

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

research Polycystic Ovary Syndrome: Comprehensive Overview

257 citations , July 2018 in “Obstetrics & Gynecology”

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

research Hyperandrogenemia in Women with Polycystic Ovary Syndrome: Prevalence, Characteristics, and Association with Body Mass Index

19 citations , January 2017 in “Hormone Molecular Biology and Clinical Investigation”

High levels of male hormones are very common in women with PCOS and affect their metabolism differently depending on their weight.

research Prostate Specific Antigen in Diagnosis of Polycystic Ovarian Syndrome: A New Insight

6 citations , July 2016 in “Gynecological Endocrinology”

PSA levels are higher in women with PCOS, but FAI is a more accurate marker for diagnosis.

American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

343 citations , October 2015 in “Endocrine Practice”

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

research Clinical Biochemistry of Dihydrotestosterone

50 citations , February 2013 in “Annals of Clinical Biochemistry”

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

research Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

926 citations , June 2010 in “BMC Medicine”

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

research Prevalence of Hyperandrogenemia in Polycystic Ovary Syndrome Diagnosed by the National Institutes of Health 1990 Criteria

118 citations , February 2009 in “Fertility and Sterility”

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

research Is It Necessary to Measure Free Testosterone to Assess Hyperandrogenemia in Women? The Role of Calculated Free and Bioavailable Testosterone

22 citations , May 2006 in “Experimental and Clinical Endocrinology & Diabetes”

Calculated testosterone values are reliable for assessing hyperandrogenemia in women, making direct measurement unnecessary.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations , December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

research Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

66 citations , November 2001 in “European journal of endocrinology”

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

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research Current Aspects of Polycystic Ovary Syndrome: A Literature Review

15 citations , December 2016 in “Revista Da Associacao Medica Brasileira”

Polycystic ovary syndrome is a common hormonal disorder in women, linked to increased risk of metabolic and heart diseases, and needs more research for better understanding and treatment.

research Polycystic Ovary Syndrome and Acne

10 citations , January 2011 in “Skin therapy letter”

Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.

research The Diagnosis of Polycystic Ovary Syndrome in Adolescents

212 citations , May 2010 in “American Journal of Obstetrics and Gynecology”

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.