Hyperandrogenemia in Women with Polycystic Ovary Syndrome: Prevalence, Characteristics, and Association with Body Mass Index

January 2017 in “ Hormone Molecular Biology and Clinical Investigation ”

Eleni Alexiou, Erifili Hatziagelaki, Vasilios Pergialiotis, Charalampos Chrelias, Dimitrios Kassanos, Charalampos Siristatidis, Giannoula Kyrkou, Maria Kreatsa, Eftihios Trakakis

hyperandrogenemia polycystic ovary syndrome PCOS testosterone free testosterone androstenedione 17-hydroxyprogesterone DHEAS cortisol HOMA-IR white blood cells neutrophils T FT A4-A 17-OHP WBC

Studysummary This study found a high prevalence of hyperandrogenemia in women with PCOS, with distinct biochemical differences according to BMI and presence of hyperandrogenemia.

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Research cited in this study

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research The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

767 citations , September 2016 in “Human Reproduction”

This review analyzes the reported prevalence of polycystic ovary syndrome (PCOS) based on different diagnostic criteria but does not provide new clinical results.

research Androgen Excess: Investigations and Management

82 citations , May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

This article outlines the clinical features, evaluation, and treatment strategies for androgen excess in polycystic ovary syndrome, highlighting important diagnostic and management approaches but reporting no new research results.

research Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome

53 citations , December 2015 in “JAMA Dermatology”

This study found that hirsutism and acanthosis nigricans are the most reliable skin markers for diagnosing polycystic ovary syndrome in women and suggest a need for further evaluation of possible metabolic issues.

research Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study

71 citations , July 2015 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that women with PCOS have elevated serum androgen levels throughout adulthood, with these levels decreasing and variations increasing as they approach menopause.

research Elevated Serum Androstenedione Is Associated With a More Severe Phenotype in Women With Polycystic Ovary Syndrome

28 citations , April 2014 in “Hormones”

This study found that increased serum A4A levels were associated with more severe polycystic ovary syndrome phenotypes and could be a useful marker for biochemical hyperandrogenemia.

research Cutaneous Manifestations of the Subtypes of Polycystic Ovary Syndrome in Korean Patients

16 citations , March 2014 in “Journal of the European Academy of Dermatology and Venereology”

This study found that acne was the most common dermatological manifestation in Korean women with polycystic ovary syndrome, particularly those with a specific combination of symptoms, showing distinct variations in serum hormonal and metabolic parameters.

Prevalence of Androgenic Alopecia in Patients with Polycystic Ovary Syndrome and Characterization of Associated Clinical and Biochemical Features

research Prevalence of Androgenic Alopecia in Patients with Polycystic Ovary Syndrome and Characterization of Associated Clinical and Biochemical Features

48 citations , February 2014 in “Fertility and Sterility”

This study found that androgenic alopecia is present in 22% of women with polycystic ovary syndrome and is associated with acne and hirsutism, but not with increased biochemical hyperandrogenemia or metabolic dysfunction beyond PCOS.

The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

research The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

221 citations , January 2014 in “Human Reproduction”

This study found that the prevalence of polycystic ovary syndrome was 16.6% with Rotterdam criteria but decreased to 6.3% or 8.5% when using alternative criteria involving antral follicle count or anti-Müllerian hormone.

research Prevalence of Hyperandrogenemia in Polycystic Ovary Syndrome Diagnosed by the National Institutes of Health 1990 Criteria

118 citations , February 2009 in “Fertility and Sterility”

This study found that approximately 75% of women with PCOS exhibited hyperandrogenemia, with free testosterone being the most frequently elevated marker.