Prostate Specific Antigen in Diagnosis of Polycystic Ovarian Syndrome: A New Insight

July 2016 in “ Gynecological Endocrinology ”

Ewa Rudnicka, Stanisław Radowicki, Katarzyna Suchta

prostate specific antigen PSA polycystic ovarian syndrome PCOS total PSA TPSA free PSA fPSA total testosterone tT free androgen index FAI hyperandrogenism area under the curve AUC receiver operating characteristic ROC

TLDR PSA levels are higher in women with PCOS, but FAI is a more accurate marker for diagnosis.

The study from 2016 investigated the use of prostate specific antigen (PSA) as a diagnostic marker for polycystic ovarian syndrome (PCOS) by comparing PSA levels in 165 women with PCOS to those in 40 healthy controls. Results showed that total PSA (TPSA) levels were significantly higher in the PCOS group, with a positive correlation to total testosterone (tT) and the free androgen index (FAI), a marker for hyperandrogenism. However, free PSA (fPSA) levels were undetectable in all participants. The study did not find a correlation between TPSA and metabolic parameters like glucose and insulin, possibly due to the participants' normal BMI. Although TPSA may be a potential marker for hyperandrogenism, FAI was found to have better diagnostic accuracy for PCOS, with an area under the curve (AUC) of 82.1% compared to 66.3% for TPSA in receiver operating characteristic (ROC) analysis. The study suggests that further research is needed to confirm the role of TPSA in diagnosing PCOS and other androgen excess disorders.

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Research cited in this study

2 / 2 results

research Is Prostate-Specific Antigen a Potential New Marker of Androgen Excess in Polycystic Ovary Syndrome?

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Prostate Specific Antigen in Diagnosis of Polycystic Ovarian Syndrome: A New Insight

Research cited in this study

research Is Prostate-Specific Antigen a Potential New Marker of Androgen Excess in Polycystic Ovary Syndrome?

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

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