TLDR New methods can detect finasteride's major urinary metabolite in urine for up to 49 hours.
The study developed and validated a sensitive method for detecting carboxy-finasteride, the major urinary metabolite of finasteride, using LC–MS and LC–MS/MS, achieving a limit of detection of 2 ng/mL. This method addressed challenges in doping control, as finasteride is used as a masking agent, and demonstrated good precision and accuracy. It was successfully applied to urine samples from a male volunteer, showing carboxy-finasteride elimination peaked at 10 hours post-administration. The method met WADA requirements and was suitable for routine analysis to detect finasteride misuse in sports.
22 citations
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July 2010 in “Drug Testing and Analysis” A quick method was developed to detect banned substances in urine for doping control.
39 citations
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April 2007 in “Therapeutic Drug Monitoring” Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
12 citations
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June 2006 in “British Journal of Sports Medicine” Doping in football faces legal challenges with testosterone limits, hair loss treatments, and recreational drug use.
49 citations
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December 2017 in “Journal of pharmaceutical and biomedical analysis” The method effectively detects banned substances in urine for sports antidoping.
39 citations
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April 2007 in “Therapeutic Drug Monitoring” Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
2 citations
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December 2013 in “Xenobiotica” Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.
13 citations
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November 2014 in “Toxicology Letters” Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.
February 2025 in “Drug Testing and Analysis” All samples tested negative for banned substances, ensuring competition integrity.
