In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

November 2014 in “ Toxicology Letters ”

Seung Hwan Lee, Jung Tak Park, Do-Yun Kim, Soo Kyung Bae, Young-Won Chin, Euichaul Oh

finasteride UGT1A4 drug-drug interactions Propecia

Studysummary This study found that finasteride selectively inhibited UGT1A4 in vitro but is unlikely to cause clinically significant drug interactions mediated through hepatic UGT enzymes in vivo. Our plain-language summary of this paper — not a Tressless recommendation.

The study found that finasteride selectively inhibits the UGT1A4 enzyme in vitro, which could potentially lead to drug-drug interactions in vivo. However, the in vivo concentration of finasteride is not high enough to cause significant inhibition of UGT1A4. The study suggests that caution should be taken when administering drugs that are metabolized by UGT1A4 in combination with finasteride.

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The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

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