Metabolism of Finasteride in Rat Hepatic Microsomes: Age and Sex Differences and Effects of P450 Inducers

    September 1994 in “ Xenobiotica ”
    Yoshio Ishii, Harutaka Mukoyama, Satoshi Hata
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    TLDR Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.
    The study investigated the metabolism of finasteride in rat hepatic microsomes, focusing on age and sex differences and the effects of P450 inducers. The results showed that the metabolism of finasteride was affected by age and sex, with male rats metabolizing the drug faster than female rats. Additionally, the study found that P450 inducers increased the metabolism of finasteride in both male and female rats. These findings suggest that the metabolism of finasteride may be influenced by various factors and should be taken into consideration when prescribing the drug.
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