In Vitro Biotransformation of Finasteride in Rat Hepatic Microsomes: Isolation and Characterization of Metabolites
January 1994
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6 / 1000+ resultscommunity How does finasteride leave your body?
in Chat 13 upvotes 2 years ago Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.
community Sensitive liver, topical fin safe to try?
in Finasteride 98 upvotes 10 months ago Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.
community Is this true? Is long term taking fin harmful to the liver?
in Chat 127 upvotes 2 years ago The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).
community What blood results (if any) could be affected by Fin/Min?
in Finasteride/Dutasteride 2 upvotes 1 year ago Finasteride can increase total testosterone and potentially raise estrogen levels, leading to side effects. Biotin in combined tablets can falsely elevate thyroid hormone levels in blood tests.
community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)
in Research/Science 5 upvotes 2 months ago Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.
community Finasteride affects both 5a reductase and 5b reductase
9 upvotes 6 years ago Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.