High-Resolution Mass Spectrometric Investigation of the Phase I and II Metabolites of Finasteride in Pig Plasma, Urine, and Bile

    December 2013 in “ Xenobiotica ”
    Anna Lundahl, Annica Tevell Åberg, Ulf Bondesson, Hans Lennernäs, Mikael Hedeland
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    TLDR Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.
    This study investigated the metabolite profile of finasteride in pig plasma, urine, and bile using high-resolution mass spectrometry. The study found that the pig formed the phase I metabolites MX and MY and their glucuronides, which is consistent with previous human studies. The study also provided insight into the CYP enzymes involved in the formation of MX and MY, with human recombinant CYP3A4 producing both metabolites and CYP2D6 producing a metabolite similar to MY. The study concludes that the pig is a valid in vivo model for human drug studies.
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