High-Resolution Mass Spectrometric Investigation of the Phase I and II Metabolites of Finasteride in Pig Plasma, Urine, and Bile
December 2013
in “
Xenobiotica
”
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Studysummary This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.
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This study investigated the metabolite profile of finasteride in pig plasma, urine, and bile using high-resolution mass spectrometry. The study found that the pig formed the phase I metabolites MX and MY and their glucuronides, which is consistent with previous human studies. The study also provided insight into the CYP enzymes involved in the formation of MX and MY, with human recombinant CYP3A4 producing both metabolites and CYP2D6 producing a metabolite similar to MY. The study concludes that the pig is a valid in vivo model for human drug studies.
