High-Resolution Mass Spectrometric Investigation of the Phase I and II Metabolites of Finasteride in Pig Plasma, Urine, and Bile

    December 2013 in “ Xenobiotica ”
    Anna Lundahl, Annica Tevell Åberg, Ulf Bondesson … Mikael Hedeland
    Studysummary This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.
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    Research cited in this study 6

    1. In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole Drug Metabolism and Disposition · 2011
    2. Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry Drug Metabolism and Disposition · 2009
    3. The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men European Journal of Pharmaceutical Sciences · 2008
    4. Metabolism of Finasteride in Rat Hepatic Microsomes: Age and Sex Differences and Effects of P450 Inducers Xenobiotica · 1994
    5. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994
    6. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993