In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

    February 2011 in “ Drug Metabolism and Disposition ”
    Anna Lundahl, Mikael Hedeland, Ulf Bondesson, Hans Lennernäs
    Studysummary This study examined the pharmacokinetics of finasteride in pigs and found that ketoconazole coadministration affected its distribution across various plasma compartments, bile, and urine.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on dmd.aspetjournals.org →
    Discuss this study in the Community →

    Research cited in this study 6

    1. Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics Drug Metabolism and Pharmacokinetics · 2010
    2. Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry Drug Metabolism and Disposition · 2009
    3. The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men European Journal of Pharmaceutical Sciences · 2008
    4. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    5. Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine The Journal of Clinical Pharmacology · 1993
    6. Finasteride: The First 5 Alpha-Reductase Inhibitor PubMed · 1993

    Related research 1

    1. The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men European Journal of Pharmaceutical Sciences · 2008