Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

    July 2009 in “ Drug Metabolism and Disposition ”
    Anna Lundahl, Hans Lennernäs, Lars Knutson, Ulf Bondesson, Mikael Hedeland
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    TLDR Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
    This document reports on the identification of finasteride metabolites in human bile and urine using high-performance liquid chromatography/tandem mass spectrometry. The study identified two novel metabolites of finasteride, MX and MY, in human bile and urine, and found that glucuronidation was the most important conjugation pathway for the finasteride phase I metabolites. The study provides new information about the metabolism of finasteride, which is important for understanding the safety and efficacy of the drug.
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