TLDR Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
This document reports on the identification of finasteride metabolites in human bile and urine using high-performance liquid chromatography/tandem mass spectrometry. The study identified two novel metabolites of finasteride, MX and MY, in human bile and urine, and found that glucuronidation was the most important conjugation pathway for the finasteride phase I metabolites. The study provides new information about the metabolism of finasteride, which is important for understanding the safety and efficacy of the drug.
Cited in this study
7 / 7 results
33 citations
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March 2009 in “European Journal of Pharmaceutical Sciences” St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.
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January 1996 in “Journal of Pharmaceutical Sciences” Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.
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January 1996 in “Clinical Pharmacokinectics” Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.
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August 1994 in “Journal of Chromatography B: Biomedical Sciences and Applications” Method detects finasteride in plasma and semen with high sensitivity and accuracy.
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July 1993 in “Pharmacotherapy” Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.
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June 1993 in “Biochemistry” Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
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October 1992 in “The New England Journal of Medicine” Finasteride effectively treats BPH but may increase sexual dysfunction risk.