Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

    July 2009 in “ Drug Metabolism and Disposition ”
    Anna Lundahl, Hans Lennernäs, Lars Knutson … Mikael Hedeland
    Studysummary This study identified previously unknown phase I and phase II metabolites of finasteride in human bile and urine using a specialized bile collection technique and advanced mass spectrometry analysis.
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    Research cited in this study 7

    1. The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men European Journal of Pharmaceutical Sciences · 2008
    2. In Vivo Time-Dependent Inhibition of Human Steroid 5α-Reductase by Finasteride Journal of Pharmaceutical Sciences · 1996
    3. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    4. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994
    5. Finasteride: The First 5α-Reductase Inhibitor Pharmacotherapy · 1993
    6. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993
    7. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992