TLDR Finasteride's metabolites were identified, helping understand how the drug is processed in the body.
The study focused on identifying the metabolites of finasteride, a 5α-reductase inhibitor, using mass spectrometry both in vitro and in vivo. The research successfully identified several metabolites of finasteride, providing insights into its metabolic pathways. This information was crucial for understanding the drug's pharmacokinetics and potential effects on the body. The findings contributed to the broader knowledge of how finasteride is processed in the body, which was important for its therapeutic use, particularly in conditions like androgenetic alopecia and benign prostatic hyperplasia.
20 citations
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August 2014 in “Talanta” The method effectively measures drug impact on DHT levels in prostate treatments.
2 citations
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December 2013 in “Xenobiotica” Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.
Finasteride is extensively metabolized in the body, affecting its effectiveness and safety.
The study investigated the impact of St. John’s wort on the pharmacokinetics of finasteride and identified new phase I and phase II metabolites in humans. It was found that St. John’s wort significantly altered the pharmacokinetics of finasteride, potentially affecting its efficacy. The research also led to the discovery of new metabolites, which provided further insight into the metabolic pathways of finasteride. This study highlighted the importance of considering herbal supplements like St. John’s wort when evaluating drug interactions and their potential effects on drug metabolism.
13 citations
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October 2005 in “Analytical Sciences” A new method was developed to measure and assess the activity and inhibition of the enzyme steroid 5α-reductase.