Identification of Hydroxylated and Glucuronidated Metabolites of Finasteride in Human Bile and Urine

January 2009

Anna Lundahl, Hans Lennernäs, Lars Knutson, Ulf Bondesson, Mikael Hedeland

finasteride hydroxylated metabolites glucuronidated metabolites androgenetic alopecia benign prostatic hyperplasia Propecia

TLDR Finasteride is extensively metabolized in the body, affecting its effectiveness and safety.

The study identified hydroxylated and glucuronidated metabolites of finasteride in human bile and urine. This research contributed to the understanding of finasteride's metabolic pathways, which was important for assessing its pharmacokinetics and potential side effects. The findings were presented at the Young Pharmaceutical Scientist Meeting, highlighting the significance of analytical pharmaceutical chemistry in drug metabolism studies.

View this study on diva-portal.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

in Minoxidil 37 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community I've been afflicted by post finasteride syndrome, what now?

in Finasteride 41 upvotes 6 years ago

A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1065 upvotes 2 years ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 99 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Personal results (1mg finasteride + 10.000mcg biotine) after almost 3 years. Not as impressive as some here, but maybe provides a more realistic view.

in Progress Pictures 479 upvotes 3 years ago

Jericho1017 shared their hair regrowth results after nearly 3 years using 1mg finasteride and 10,000mcg biotin daily, with noticeable improvement after 1.5 years and no significant side effects except for watery semen. Some users suggested adding minoxidil and microneedling to improve results, but Jericho1017 is currently content with their progress and not looking to add more treatments.

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

130 upvotes 7 years ago

Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

Related Research

4 / 4 results

research High-Resolution Mass Spectrometric Investigation of the Phase I and II Metabolites of Finasteride in Pig Plasma, Urine, and Bile

2 citations , December 2013 in “Xenobiotica”

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

research In Vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites

1 citations , January 2010

Finasteride is mainly broken down by the enzyme CYP3A4, affecting its levels in the body.

Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

research Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

18 citations , July 2009 in “Drug Metabolism and Disposition”

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

research Metabolite Identification by Mass Spectrometry of the 5α-Reductase Inhibitor Finasteride In Vitro and In Vivo

January 2009

Finasteride's metabolites were identified, helping understand how the drug is processed in the body.