Identification of Human Cytochrome P450 Isozymes Responsible for the In Vitro Oxidative Metabolism of Finasteride

October 1995 in “ PubMed ”

Su-Er W. Huskey, D. J. Dean, R. J. Miller, Gary H. Rasmusson, Shuet-Hing Lee Chiu

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community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 1 year ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community Very high testosterone and estradiol on finasterid 1 mg. Am I cooked?

in Finasteride/Dutasteride 3 upvotes 3 months ago

A 29-year-old male on 1 mg Finasteride for 3 months has experienced a significant increase in testosterone and estradiol levels, with no major side effects except slightly oilier skin and increased emotional sensitivity. The user is concerned about these hormonal changes and seeks advice, as their general practitioner is not knowledgeable about the issue.

community Getting bloods done whilst on finasteride

in General 98 upvotes 10 months ago

Finasteride can affect hormone levels within two weeks, and a break of several weeks is recommended for baseline results. Monitoring E2 and testosterone is suggested to assess the risk of gynecomastia.

community Stemoxydine carrier for finasteride

in Treatment 7 upvotes 2 years ago

User wants to mix finasteride into stemoxydine instead of minoxidil. Seeks stemoxydine brand recommendations for mixing in the UK.

community Got Blood Work Lab Results for hormones. Need some help analyzing hormone values for Fin

in Finasteride/Dutasteride 6 upvotes 3 years ago

The user got blood work to check hormone levels before starting Finasteride for hair loss and is seeking advice on interpreting the results. They are considering hormone levels in relation to potential side effects of Finasteride.

community My Estradiol Level on Finasteride

in Research/Science 18 upvotes 9 months ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.