The Postnatal Offspring of Finasteride-Treated Male Rats Show Altered ERα and PCNA Expression in the Liver

    July 2025 in “ Reproductive Biology ”
    Agnieszka Kolasa, Paulina Kur, Sylwia Rzeszotek, Marta Grabowska, Małgorzata Blatkiewicz, Marika Freus, Aleksandra Wilk
    TLDR Finasteride use in male rats may harm their male offspring's liver function.
    The study investigates the intergenerational effects of finasteride, a drug used by male rats, on the liver function of their male offspring. It was found that finasteride treatment in the paternal generation led to altered expression of estrogen receptor alpha (ERα) and proliferating cell nuclear antigen (PCNA) in the liver of the offspring. The research involved analyzing liver samples from immature and mature Wistar male rats, revealing significant differences in ERα and PCNA expression between the offspring of finasteride-treated and untreated males. These findings suggest that finasteride use by males of reproductive age may have detrimental effects on the liver function of their male progeny, highlighting potential implications for hormone-dependent diseases.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 1000+ results

      community Nandrolone Replacement Therapy

      in Treatment  41 upvotes 2 years ago
      A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 2 years ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

      community Finasteride vs Dutasteride: The Science

      in Research/Science  166 upvotes 1 year ago
      The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

    Related Research

    6 / 6 results