Finasteride 1 mg Has No Inhibitory Effect on Omeprazole Metabolism in Extensive and Poor Metabolizers for CYP2C19 in Japanese

    September 2006 in “ European Journal of Clinical Pharmacology ”
    Toshio Yasumori, Hideo Narita, T. Matsuda, Takayuki Takubo, Michio Ogawa, Mamoru Ishii, Kazuhiko Hara, Yoshio Ishii, Kikuo Okuyama, G. Fujimoto, H Ochiai, Akihiro Kano, Satoshi Hasegawa, Koji Sato, Takashi Taniguchi
    Image of study
    TLDR Finasteride doesn't affect omeprazole metabolism in Japanese people.
    The study investigated whether finasteride, a drug used to treat hair loss, inhibits the metabolism of omeprazole, a drug used to treat acid reflux, in Japanese individuals with different metabolizer types for CYP2C19. The study found that finasteride had little inhibitory effect on omeprazole metabolism in either group, indicating that finasteride has little inhibitory effect on CYP2C19 activity in vivo at the dose of 1 mg/day. Therefore, it was confirmed that multiple oral doses of finasteride at 1 mg/day did not affect in vivo CYP2C19 activities in humans. The study concluded that a multiple dose of finasteride 1 mg with a single dose of omeprazole 20 mg is as safe as with the administration of omeprazole 20 mg alone.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 1000+ results

      community Temporary alternative to finasteride?

      in Finasteride  87 upvotes 5 days ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

      community Sensitive liver, topical fin safe to try?

      in Finasteride  98 upvotes 1 week ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

      community 8 months Fin + Oral Minox - still losing some hairs, normal?

      in Finasteride  90 upvotes 1 week ago
      After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

    Similar Research

    5 / 1000+ results