research 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia
Increased Treg cells and IL-10 may help quick recovery in acute diffuse and total alopecia.
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research iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata
In this study, iNKT10 cells were found to play a significant role in preventing and treating alopecia areata in a humanized mouse model, suggesting these cells could have potential in managing related autoimmune disorders.
research A systematic review of tumor necrosis factor-α blockers, anti-interleukins, and small molecule inhibitors for dissecting cellulitis of the scalp treatment
This review suggests that immunomodulators, including TNF-α blockers and IL inhibitors, may improve symptoms of moderate-to-severe dissecting cellulitis of the scalp, but their effects on hair regrowth and scarring remain unclear.
research The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm
This review discusses recent advances and ongoing clinical trials in novel therapeutics for alopecia areata, despite the lack of current FDA-approved treatments for severe cases, and reports no new results.
research COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine
This paper discusses the variability in COVID-19 susceptibility and severity, emphasizing factors like biological differences and suggesting potential precision medicine approaches, but it reports no new clinical results.
research A novel therapeutic paradigm for patients with extensive alopecia areata
This review discusses immune pathways involved in alopecia areata and explores emerging, more targeted therapeutic strategies, noting their potential for better safety and effectiveness compared to traditional immune suppressants.
research Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells
This study found that a newly developed injectable hydrogel combined with human umbilical cord-mesenchymal stem cells significantly accelerated wound healing and reduced inflammation in full-thickness cutaneous wounds.
research Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
This literature review explores the role of biomarkers in personalized medicine for various dermatological conditions like Hidradenitis Suppurativa, Psoriasis, and Atopic Dermatitis, highlighting how they guide targeted therapies and the limitations of current markers in specificity, as reported by the authors.
research Poster Presentations
This case study reports a 70-year-old man with treatment-resistant pityriasis rubra pilaris achieving complete clinical remission with ustekinumab, adding to evidence supporting biologic therapy when TNF inhibitors are unsuitable.
research Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review
This review explored the relationship between autoimmune thyroiditis and various autoimmune skin conditions, highlighting shared genetic markers and immunological mechanisms, such as disrupted immune tolerance and oxidative stress, which may contribute to the development of these disorders.
research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia
This study found that 1,550-nm Er:Glass fractional laser treatment increased hair density and shaft diameter in patients with androgenetic alopecia, but did not up-regulate Wnt10A and IGF-1 mRNA expression.
research Present and Future Use of Exosomes in Dermatology
This review discusses the potential of exosomes as cell-free treatments for skin aging and various dermatological diseases, highlighting their role in preventing scarring and promoting wound healing, while acknowledging the need for further research and quality control methodologies.
research Innovative Nanomedicine Approaches for Psoriasis: Advancements, Challenges, and Future Directions
This review summarizes recent advances in nanomedicine-based therapies for psoriasis, highlighting their potential to provide targeted and sustained therapeutic effects by modulating key cellular components and signaling pathways involved in the disease, offering novel perspectives for future treatment development.
research The concealed side of caspases: beyond a killer of cells
This study reviews recent advancements in understanding caspases, highlighting their roles beyond apoptosis in cancer, inflammation, and neurological disorders, and discusses the potential and challenges of targeting caspases for therapeutic purposes.
research Clinical evidence for JAK inhibition in alopecia areata: A comprehensive review
JAK inhibitors effectively regrow hair in alopecia areata but hair loss often returns after stopping treatment.
research Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischaemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model
This study suggests that hair follicle mesenchymal stem cells may alleviate small intestinal ischaemia-reperfusion injury in rats by promoting angiogenesis, reducing apoptosis, and protecting intestinal mucosal function.
research Association of Serum IL-17A and IL-23 Levels With Alopecia Areata: A Cross-Sectional Comparative Study
This study suggests that elevated levels of IL-17A and IL-23 in alopecia areata may play roles in disease severity and activity, providing insights into potential therapeutic targets.
research Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma
This study found that microRNA levels in hair shafts were significantly decreased in scleroderma patients compared to normal subjects, suggesting they may serve as effective biomarkers.
research Recombinant Human Growth Hormone Promotes Burn Wound Repair by Regulating Vascular Endothelial Growth Factor and Micro Vessel Density
In this animal study, rats treated with recombinant human growth hormone (at both low and high doses) experienced quicker burn wound healing than controls, with increased micro vessel density and altered expression of vascular endothelial growth factor, alongside changes in oxidative stress and inflammation markers.
research AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis
This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.
research Zinc deficiency and its management in the pediatric population: A literature review and proposed etiologic classification
This review examines skin symptoms, diagnosis, and treatment of zinc deficiency in children, proposing a classification system but reporting no new clinical results.
research Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis
In this study, CD4+ non-haematopoietic, skin-resident stem cell-like populations were identified in both murine and human epidermis, suggesting they may serve as potential basal cell carcinoma precursors.
research Az alopecia areata kezelésében alkalmazott baricitinib hatásosságának és biztonságosságának retrospektív vizsgálata = Efficacy and safety of baricitinib treatment in alopecia areata:a retrospective analysis
In this study, baricitinib was found to be effective and safe for treating severe alopecia areata, with significant hair regrowth observed in many patients by the third month of therapy and continued improvement by the twelfth month, despite mostly mild adverse events.
research A comprehensive review of the medical complications associated with restrictive eating behaviors in anorexia nervosa
In this review, researchers reported that anorexia nervosa leads to widespread medical complications across all body systems, particularly at low body weights, and these complications are primarily treated through nutritional rehabilitation with a multidisciplinary team approach.
research The Incidence of Alopecia Areata in a COVID-19-Vaccinated Population: A Single-Center Review
This study in a California safety net hospital found no apparent increase in alopecia areata incidence among individuals who received COVID-19 vaccination compared to those unvaccinated, with odds ratios indicating a lower risk in the vaccinated group.
research Role of topical tofacitinib in autoimmune skin disorders: An expert opinion
This source discusses the potential of topical JAK inhibitors, like tofacitinib, as effective treatments for autoimmune skin diseases, emphasizing their superior safety profile and minimal adverse effects compared to conventional systemic therapies.
research Homoeopathic intervention in classic case of alopecia areata: A case study
This abstract discusses alopecia areata, highlighting its complex autoimmune pathogenesis involving immune cells and signaling molecules, and underscores the importance of accurate diagnosis and tailored management strategies, noting the need for further research to improve treatments.
research Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages
This study found that the PSEN1-P242LfsX11 mutation in hidradenitis suppurativa influences cytokine and chemokine expression in macrophages, potentially affecting inflammatory responses.
research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration
This review discusses the mechanisms and potential therapeutic benefits of mesenchymal stromal cell-derived extracellular vesicles delivered via biomaterials, but reports no new clinical results.
research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing
This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.