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    A Systematic Review of Tumor Necrosis Factor-α Blockers, Anti-Interleukins, and Small Molecule Inhibitors for Dissecting Cellulitis of the Scalp Treatment

    May 2025 in “ Orphanet Journal of Rare Diseases ”
    Nazila Heidari, Rad Ghannadzadeh Kermani Pour, Melina Farshbafnadi … Yekta Ghane
    Studysummary This review suggests that immunomodulators, including TNF-α blockers and IL inhibitors, may improve symptoms of moderate-to-severe dissecting cellulitis of the scalp, but their effects on hair regrowth and scarring remain unclear.
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    Research cited in this study 11

    1. Tumor Necrosis Factor Inhibitors and Janus Kinase Inhibitors in the Treatment of Cicatricial Alopecia: A Systematic Review PloS one · 2024
    2. Improvement of Recalcitrant Dissecting Cellulitis of the Scalp After a Trial of Upadacitinib Curēus · 2024
    3. Autologous Adipose Tissue Injection in the Treatment of Alopecia: A Mini-Review Journal of Cosmetic Dermatology · 2023
    4. Refractory Dissecting Cellulitis of the Scalp Treated With Risankizumab: 2 Case Reports JAAD Case Reports · 2023
    5. Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm Dermatology and therapy · 2023
    6. Perifolliculitis Capitis Abscedens Et Suffodiens Treatment With Tumor Necrosis Factor Inhibitors and Baricitinib: A Case Report and Literature Review Frontiers in medicine · 2023
    7. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    8. Demographic and Histopathological Evaluation in 71 Patients Diagnosed with Dissecting Cellulitis of the Scalp Dermatologic therapy · 2023
    9. The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside Frontiers in immunology · 2020
    10. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    11. Dissecting Cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): A Comprehensive Review Focusing on New Treatments and Findings of the Last Decade with Commentary Comparing the Therapies and Causes of Dissecting Cellulitis to Hidradenitis Suppurativa Dermatology Online Journal · 2014