Systematic Review of Pharmacotherapy Strategies in the Management of Hidradenitis Suppurativa

    September 2025 in “ International Journal of Innovative Technologies in Social Science ”
    Natalia Nafalska, Małgorzata Stopyra, Krzysztof Feret, Aleksandra Ćwirko-Godycka, Kamil Kerknawi, Paulina Mikulec, Angelika Kędzierska, Michael Bär, Mikołaj Bluszcz, Ryszard Feret
    From the encyclopedia
    Spironolactone →

    powerful topical and oral anti-androgen used mostly by women

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

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    Studysummary This review highlights that while pharmacotherapy, including biological agents, provides varying but often partial control of hidradenitis suppurativa depending on disease severity, significant challenges and high relapse rates persist, necessitating further research for more effective treatments.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The systematic review examines pharmacotherapy strategies for managing hidradenitis suppurativa (HS), emphasizing the efficacy of biologic agents like adalimumab, secukinumab, and bimekizumab in moderate to severe cases, particularly when conventional treatments fail. Antibiotics, such as clindamycin and tetracyclines, are commonly used but are limited by high relapse rates and potential resistance. Anti-androgen therapies, including spironolactone and finasteride, show benefits, especially in hormonally driven cases in women. The review highlights the need for individualized treatment plans and further research into HS's complex pathophysiology to develop more targeted therapies.
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