Recombinant Human Growth Hormone Promotes Burn Wound Repair by Regulating Vascular Endothelial Growth Factor and Microvessel Density

The study investigated the effects of recombinant human growth hormone (rhGH) on burn wound healing in 60 rats, divided into three groups: control (group A), low-dose rhGH (group B), and high-dose rhGH (group C). Results showed that both rhGH groups (B and C) had shorter scab removal and hair growth times compared to the control. Vascular endothelial growth factor (VEGF) expression and micro vessel density were higher in the rhGH groups, with the highest levels in group C. Additionally, oxidative stress and inflammation markers were improved in the rhGH groups, with group C showing the most significant improvements. The study concludes that rhGH promotes burn wound repair by enhancing VEGF expression and micro vessel density.