13 citations
,
September 2017 in “Oncotarget” This study suggests that increased Wnt signaling may cause melanocyte stem cell exhaustion, leading to hair graying in aged mice by promoting excessive differentiation of melanocytes.
11 citations
,
November 2021 in “JBMR plus” This review discusses the role of the unliganded vitamin D receptor in hair follicle cycling and tumor formation in mice and reports no new experimental findings.
9 citations
,
July 2022 in “EMBO molecular medicine” This study found that targeting IL-6, IL-1, and CCR6 signaling pathways may effectively reduce irradiation-induced alopecia and dermatitis in radiotherapy patients.
9 citations
,
November 2013 in “BMC Pharmacology and Toxicology” This study found that transient inhibition of eIF4E in a transgenic mouse model protected against cyclophosphamide-induced hair loss by inducing cell cycle arrest and reducing cellular apoptosis.
9 citations
,
July 2025 in “Pharmaceuticals” This review highlights the therapeutic potential of plant-derived exosomes, noting their larger size compared to animal-derived exosomes and usefulness in targeted drug delivery and inter-kingdom communication. It summarizes existing research on their biogenesis, characterization, and engineering for drug delivery, indicating significant opportunities for biotechnological advancements.
8 citations
,
January 2025 in “Cell Transplantation” This review discusses the advances and challenges of using mesenchymal stem cell-derived extracellular vesicles in therapeutic applications and reports no new clinical findings.
8 citations
,
August 2020 in “International Journal of Molecular Sciences” This study found that in Arabidopsis root hairs, oscillating cytoplasmic potassium dynamics precede growth oscillations, suggesting a complex interplay with calcium signaling and microfilament structure in regulating root hair growth.
7 citations
,
July 2024 in “Current Issues in Molecular Biology” This review examines the complex mechanisms that regulate skin stem cell development, activation, and differentiation, emphasizing the molecular signaling pathways that influence their fate and contribute to skin homeostasis.
6 citations
,
October 2020 in “Frontiers in cell and developmental biology” This study found that WWOX deficiency in mice leads to impaired skin development, reduced epidermal thickness, and significant hypothermia due to disrupted cell proliferation and homeostasis.
6 citations
,
September 2012 in “Our Dermatology Online” This review discusses the off-label uses of retinoids in dermatology, focusing on oral isotretinoin and acitretin, and reports no new clinical results.
5 citations
,
April 2023 in “BMC Microbiology” This study found that using a shampoo containing heat-killed probiotics, GMNL-653, led to decreased dandruff and sebum production and increased hair growth in human participants, with observed microbiota shifts including changes in M. globosa and M. restricta abundance.
5 citations
,
November 2025 in “Cells” This review summarizes the roles of various cells and signaling pathways in skin wound healing, highlights deviations leading to pathological outcomes like chronic wounds, and evaluates cutting-edge approaches such as biomaterials and precision medicine to improve healing and intervention strategies.
5 citations
,
December 2024 in “Pharmaceutics” This review discusses the potential of using nanomaterial-based drug delivery systems to improve the treatment of polycystic ovary syndrome but reports no new clinical results, highlighting future research directions.
4 citations
,
January 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that the KLHL24-ΔN28 protein variant disrupts hair follicle stem cells in a mouse model, leading to premature hair loss by degrading keratin 15.
2 citations
,
August 2025 in “Microbiome” In this study conducted in female mice, maternal Faecalibacterium pathobionts combined with a low-fiber diet increased systemic inflammation and skin problems in offspring, suggesting a link to atopic dermatitis and the influence of dietary trends on chronic conditions.
2 citations
,
October 2022 in “Journal of Biomedical Science” This review discusses the potential of secretome derived from stem cells for treating alopecia areata and reports no new clinical results; the authors suggest the need for further human trials.
2 citations
,
July 2022 in “Cell Regeneration” This review discusses the complex interplay of factors controlling hair regeneration and highlights the potential for targeted clinical applications in various hair disorders, while reporting no new clinical results.
1 citations
,
October 2025 in “Journal of Microbiology and Biotechnology” This study suggests that phytochemicals from natural sources could be safer alternatives to conventional treatments for hair loss, as they may activate key pathways involved in hair growth.
1 citations
,
August 2025 in “The Egyptian Journal of Internal Medicine” This paper reviews obesity diagnosis and screening methods, emphasizing BMI's practicality in low- and middle-income countries, but provides no new clinical results.
1 citations
,
September 2023 in “Stem cell research & therapy” This review discusses how mesenchymal stromal cell-based therapy holds promise for treating age-related diseases, given its potential to target aging's pathological features, although significant challenges remain for its clinical application.
1 citations
,
July 2023 in “Frontiers in Immunology” This review highlights the role of chronic stress, oxidative stress, and immune processes in the development of Hashimoto’s thyroiditis and polycystic ovary syndrome, emphasizing the potential of antioxidants in their treatment based on the existing literature.
1 citations
,
March 2022 in “IntechOpen eBooks” This article reviews the functions and locations of skin stem cells and their role in regeneration and differentiation, relating age-associated skin changes to decreased stem cell functionality; it reports no new experimental findings.
1 citations
,
January 2022 in “Springer eBooks”
1 citations
,
July 2019 in “Journal of Dermatology and Dermatologic Surgery” This review discusses the potential of stem cell therapies for regenerating hair in nonautoimmune hair loss and calls for more studies to evaluate their efficacy.
1 citations
,
November 2023 in “Medicina” This narrative review emphasizes the significant improvements in mental well-being linked to gender-affirming treatments while highlighting the need for ongoing research into hormone therapy's long-term effects and its impact on transgender individuals' reproductive health.
February 2026 in “Journal of Cutaneous and Aesthetic Surgery” In this consensus statement, the Task Force of the Association of Cutaneous Surgeons of India found that over 90% of their experts agreed on the evidence strength, recommendation levels, and safety of six emerging dermatology treatments, providing guidelines for their clinical use.
February 2026 in “Stem Cell Research & Therapy” This review article discusses recent advances in stem cell-based therapies for Alopecia Areata, noting preliminary clinical trials show significant hair regrowth, but emphasizes the need for thorough evaluation of long-term safety and efficacy.
October 2025 in “Cell Transplantation” This review discusses recent advancements in hair loss treatments, including stem cell and hair follicle cell therapies, growth factors, extracellular vesicles, gene therapy, and tissue engineering, highlighting their potential in improving hair regeneration and follicle health.
April 2025 in “Journal of Investigative Dermatology” This study found that elevated luteinizing hormone levels were significantly associated with female pattern hair loss, and implicated LH/LHR signaling in the aging and damage of hair follicles.
November 2024 in “Stem Cell Research & Therapy” This study found that human umbilical cord mesenchymal stem cells (hUCMSCs) promoted hair regeneration in androgenetic alopecia model mice by activating Wnt/β-catenin signaling, enhancing hair follicle stem cell proliferation, and reducing dermal papilla cell apoptosis.