Image

    LH Induces Murine Hair Loss Through TRPC-Mediated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis

    April 2025 in “ Journal of Investigative Dermatology ”
    Ching‐Ying Wu, Anupama Vadhan, Wei‐Yen Wei … Wen‐Li Hsu
    Studysummary This study found that elevated luteinizing hormone levels were significantly associated with female pattern hair loss, and implicated LH/LHR signaling in the aging and damage of hair follicles.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidonline.org →
    Discuss this study in the Community →

    Research cited in this study 16

    1. Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia Patients Translational Medicine Communications · 2023
    2. Female Pattern Hair Loss: Therapeutic Update Anais Brasileiros De Dermatologia · 2023
    3. Effects of Hormones and Endocrine Disorders on Hair Growth Cureus · 2022
    4. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022
    5. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    6. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    7. Female Pattern Hair Loss AJGP · 2018
    8. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    9. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    10. The Contribution of Endogenous and Exogenous Factors to Female Alopecia Plastic and Reconstructive Surgery · 2012
    11. Hair: What Is New in Diagnosis and Management? Dermatologic Clinics · 2012
    12. From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency Stem Cells · 2010
    13. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    14. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    15. Female Pattern Hair Loss Clinical and Experimental Dermatology · 2002
    16. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996