LH Induces Murine Hair Loss Through TRPC-Mediated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis

    Ching‐Ying Wu, Anupama Vadhan, Wei‐Yen Wei, Hsin‐Su Yu, Yi‐Chun Hsieh, Wei-Chiao Chen, Chin-Chia Hsu, Yi-Hsuan Liu, Wen‐Li Hsu
    TLDR High LH levels cause hair loss by damaging and aging hair follicles.
    This study examines the role of luteinizing hormone (LH) in female-pattern hair loss (FPHL), revealing that elevated LH levels are linked to FPHL through TRPC-mediated cell aging responses. Conducted with 265 FPHL patients and 50 controls, the research shows that LH activates TRPC channels, increasing calcium ion signals and reactive oxygen species, leading to cell aging and hair follicle damage. In mice, LH treatment induced hair loss, which was mitigated by TRPC inhibitors, suggesting a potential therapeutic approach. The findings underscore the impact of LH/TRPC signaling on hair follicle aging and FPHL pathogenesis, offering insights into novel treatment strategies.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 11 results

    Similar Research

    5 / 1000+ results