Suppression of Eukaryotic Initiation Factor 4E Prevents Chemotherapy-Induced Alopecia

November 2013 in “ BMC Pharmacology and Toxicology ”

Zeina Nasr, Lukas E. Dow, Marilène Paquet, Jennifer Chu, Ravindar Kontham, Somaiah Ragam, Pierre Deslongchamps, John A. Porco, Scott W. Lowe, Jerry Pelletier

eukaryotic initiation factor 4E eIF4E chemotherapy-induced alopecia RNAi cyclophosphamide cell cycle arrest G1 phase apoptosis hair follicle cells translation initiation chemotherapy-induced hair loss RNA interference hair loss prevention

Studysummary This study found that transient inhibition of eIF4E in a transgenic mouse model protected against cyclophosphamide-induced hair loss by inducing cell cycle arrest and reducing cellular apoptosis.

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Research cited in this study

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research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Protection Against Chemotherapy-Induced Alopecia

97 citations , September 2006 in “Pharmaceutical Research”

This review discusses advances in protecting against chemotherapy-induced alopecia and reports no new clinical results; calcitriol and cyclosporine A emerged as promising agents in animal models with broader efficacy across multiple chemotherapy drugs.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

53 citations , October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that cyclophosphamide induced significant keratinocyte apoptosis in anagen hair follicles of mice, while topical calcitriol-analogs reduced this apoptosis, suggesting a protective effect against chemotherapy-induced alopecia.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations , April 1994 in “PubMed”

This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.