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This study found that platelet-rich plasma combined with micro-needling significantly increased hair density and thickness in patients with androgenetic alopecia, with mild side effects reported, though further high-quality trials are needed to validate these results and standardize treatments.

This study found that injecting growth factor concentrates into the scalp of five patients with androgenic alopecia led to notable improvements in hair density and quality over eight weeks, with patients reporting satisfaction and minimal side effects.

This study highlights that a novel radially aligned nanofiber scaffold with dual growth factor gradients significantly enhances wound healing, promoting cell migration, epidermal regeneration, and angiogenesis, ultimately leading to improved wound closure, immune regulation, and tissue remodeling compared to other groups.

In this case report, a 35-year-old man with androgenetic alopecia showed significant improvement in hair thickness and density after six months of conservative therapy with topical minoxidil, oral finasteride, and a gel with oligopeptides, caffeine, and taurine.

This study found that N,N-dimethylglycine sodium salt promoted proliferation and migration of cultured human epidermal keratinocytes and had anti-inflammatory and antioxidant effects in vitro.

In this randomized controlled trial, researchers found that Cellcurin therapy significantly increased hair density, terminal hair, and vellus hair counts in men and women with androgenetic alopecia, compared to minoxidil control, over 12 weeks.

This pilot study found that growth factor concentrate therapy improved hair growth in patients with androgenetic alopecia, was well tolerated, and achieved high patient satisfaction.

This study involved selecting patients with specific types of alopecia for treatment but does not report clinical outcomes.

Crataegi Fructus water extract may help treat hair loss.

This study found that applying a growth factor cocktail including FGF9 with microneedling significantly increased hair density and diameter in patients with androgenetic alopecia, with similar results regardless of microneedle depths between 0.5 mm and 0.8 mm.

This study found that combining CGF with IPL treatment significantly improved skin conditions and quality of life for patients with facial sensitive skin compared to IPL alone, with enhanced wrinkle reduction, skin barrier function, and decreased adverse reactions reported.

This study evaluated a novel synthetic cell-penetrating peptide, DualPep-ALO, finding it promotes hair growth by enhancing follicle cell proliferation, activating regenerative pathways, and reducing inflammation and oxidative stress in vitro and ex vivo, suggesting a promising new topical treatment for hair loss that rivals minoxidil.

This review suggests that while platelet-rich plasma has the most robust clinical evidence, platelet-rich fibrin and concentrated growth factors are gaining favor due to their ease of use and absence of additives.

This study found differential expression of growth factors and cytokines in umbilical cord blood-derived platelet-rich plasma, with the highest concentrations observed in the B blood type, but also noted weak correlations with ABO blood groups, suggesting other influencing factors.

This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.

This study found that applying a topical scalp essence with Centella asiatica extracellular vesicles and growth factors significantly improved scalp health and hair growth compared to a placebo after 56 days.

This review investigates how various intrinsic factors—such as growth factors, cytokines, chemokines, and interferons—regulate hair growth through evidence gathered from in vitro and in vivo studies, highlighting the need for further research in human subjects to validate these findings.

This review discusses recent research on the use of concentrated growth factor (CGF) for treating androgenetic alopecia, highlighting its potential to enhance hair regrowth and improve hair density but noting the need for high-quality clinical trials.

This study found that a combination of microneedling with growth factors and low-level light therapy led to visible hair regrowth without side effects in a patient with trichotillomania.

This study found that human platelet lysate, prepared from expired platelet concentrate, maintained stable growth factor levels for up to six months and improved healing in second-degree burn wounds compared to standard silver sulfadiazine treatment at three weeks.

This article reviews existing research on the treatment of alopecia areata using growth factors and microneedling, reporting that these methods show promise in promoting hair growth without major adverse effects, but emphasizes the need for additional large-scale studies to confirm their efficacy and safety.

This study suggests that high platelet concentrations in PRP may not be necessary for hair growth in androgenetic alopecia, and certain growth factors might negatively impact clinical outcomes.

Adding a cosmetic gel with caffeine, taurine, and growth factors to standard hair loss treatments could improve results.

This review examines how growth factors and cytokines influence mammalian hair growth and highlights the impact of their dysregulation, but it presents no new experimental findings.

This study found that testosterone and dihydrotestosterone can induce growth factors from dermal fibroblasts, promoting keratinocyte proliferation and differentiation, which may contribute to sex hormone-related acne development.

This study suggests that infiltrating M2 macrophages promote wound-induced hair neogenesis in mice by producing growth factors that activate the wnt signaling pathway during the late phase of wound healing.

This study found that neurotrophins produced by balding dermal papilla cells inhibited both their proliferation and hair follicle growth in vitro, suggesting a potential role in androgenetic alopecia.

Mimicking growth factors in a topical solution can prolong hair growth phase and reduce hair loss without side effects.

This study found that cyclosporin A stimulated hair growth in mouse vibrissae follicles by promoting cell proliferation, reducing apoptosis, and altering the expression of certain growth factor mRNAs.

Different substances affect hair and skin cell growth in various ways.