Cyclosporin Inhibits the Apoptosis and Affects the mRNA Expressions of Selected Growth Factors in Cultured Mouse Hair Follicles

    January 2003 in “ Journal of Clinical Dermatology ”
    Fan Wu
    TLDR Cyclosporin promotes hair growth by boosting cell growth and reducing cell death.
    The study investigated the effects of cyclosporin A (CsA) on hair growth using a mouse vibrissae organ culture model. Results showed that CsA at a concentration of 10^-7 mol/L significantly increased hair shaft elongation and decreased catagen formation, indicating enhanced hair growth. CsA also stimulated the expression of the Ki67 antigen and reduced apoptosis in hair follicle cells. Additionally, CsA treatment led to higher mRNA levels of growth factors HGF, VEGF, and NGF, while reducing follistatin mRNA levels. These findings suggested that CsA promoted hair growth by stimulating cell proliferation and inhibiting apoptosis, with changes in specific growth factor expressions contributing to its effects.
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      in Research/Science  3 upvotes 3 years ago
      The conversation discusses a hair loss treatment formulation containing cyclosporin, minoxidil, and tacrolimus, and mentions ongoing research on hair color reversal. The treatment showed high efficacy in restoring hair color in trials with 40 to 50 people.

      community Forgotten 'Total Revival' Stack

      in Research/Science  42 upvotes 6 months ago
      Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

      community Starting Way-316606 for the first time today.

      in Research/Science  30 upvotes 8 months ago
      A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.

      community The most nuclear stack possible

      in Satire  41 upvotes 8 months ago
      A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

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