Cyclosporin Inhibits the Apoptosis and Affects the mRNA Expressions of Selected Growth Factors in Cultured Mouse Hair Follicles

    January 2003 in “ Journal of Clinical Dermatology ”
    Fan Wu
    TLDR Cyclosporin promotes hair growth by boosting cell growth and reducing cell death.
    The study investigated the effects of cyclosporin A (CsA) on hair growth using a mouse vibrissae organ culture model. Results showed that CsA at a concentration of 10^-7 mol/L significantly increased hair shaft elongation and decreased catagen formation, indicating enhanced hair growth. CsA also stimulated the expression of the Ki67 antigen and reduced apoptosis in hair follicle cells. Additionally, CsA treatment led to higher mRNA levels of growth factors HGF, VEGF, and NGF, while reducing follistatin mRNA levels. These findings suggested that CsA promoted hair growth by stimulating cell proliferation and inhibiting apoptosis, with changes in specific growth factor expressions contributing to its effects.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 24 results

      community Making your own RT1640 in China

      in Research/Science 4 years ago
      RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

      community RT1640 - Gray Hair Reversal Recipe

      in Research/Science  3 upvotes 3 years ago
      The conversation discusses a hair loss treatment formulation containing cyclosporin, minoxidil, and tacrolimus, and mentions ongoing research on hair color reversal. The treatment showed high efficacy in restoring hair color in trials with 40 to 50 people.

      community Forgotten 'Total Revival' Stack

      in Research/Science  42 upvotes 10 months ago
      Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

      community Starting Way-316606 for the first time today.

      in Research/Science  30 upvotes 11 months ago
      A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.

    Related Research

    9 / 9 results