Prospect of Utilizing Expired Homologous Platelet Concentrates as an Alternative Source of Growth Factors and Cytokines in Clinical Setup for Better Wound Care and Healing

This study explored the use of expired platelet concentrates to create human platelet lysate (hPL) for wound healing, specifically for 2° burn wounds. The hPL was prepared and stored for up to 6 months, showing no significant decrease in growth factor concentration over time. In a clinical trial, patients with 2° burns treated with hPL showed better healing at 3 weeks compared to those treated with standard 1% silver sulfadiazine (SSD). The study concludes that hPL from expired platelet concentrates is a viable source of growth factors for regenerative medicine, offering an effective alternative to traditional treatments while reducing waste of biological resources.