Platelet Concentrate and Tissue Regeneration: Does It Work? A Pre-Clinical Study

This pre-clinical study investigated the effects of platelet-rich preparations, specifically Plasma Rich in Growth Factors (PRGF), on tissue regeneration. Human adipose-derived stem cells, osteoblasts, and dermal fibroblasts cultured with PRGF showed increased proliferation rates, with no adverse effects on cell viability. In osteo-differentiation, alkaline phosphatase activity was enhanced in stem cells and osteoblasts. An animal model using New Zealand rabbits with bone defects demonstrated that PRGF combined with a bone graft substitute slightly increased new bone formation, although differences were not statistically significant. Overall, the study provided evidence supporting the beneficial effects of platelet concentrates in both soft and hard tissue regeneration, suggesting potential clinical applications in regenerative therapies.