The Study of the Altering of Cytokines and Growth Factors Secreted by Cultured Balding Dermal Papilla Cells

January 2012

Ratchathorn Panchaprateep

cytokines growth factors balding dermal papilla cells neurotrophins androgenetic alopecia brain-derived nerve factor neurotrophin-3 beta-nerve growth factor hair follicle growth pathogenesis of AGA NTs neutralizing antibodies AGA BDNF NT-3 NGF

TLDR Neurotrophins may contribute to genetic hair thinning by inhibiting hair growth.

The study investigated the role of neurotrophins (NTs) in androgenetic alopecia (AGA) by examining their effects on cultured balding dermal papilla (DP) cells and hair follicle growth. It was found that NTs, specifically brain-derived nerve factor (BDNF), neurotrophin (NT)-3, and beta-nerve growth factor (NGF), were upregulated in balding DP cells compared to nonbalding ones. These NTs inhibited the proliferation of DP cells and hair follicle growth in vitro, suggesting their involvement in the pathogenesis of AGA. The study also tested the potential of NTs neutralizing antibodies to reverse these effects, but they were largely ineffective, although a reversible trend was observed. This research highlighted NTs as key factors in the development of genetic hair thinning.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 2 years ago

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community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

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Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community I bought a microscope, how does my scalp/hairs look? I've been suffering diffuse thinning and hair loss after covid and never recovered (2 yrs ago) I eat healthy, in shape and workout.

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A person with hair loss since COVID-19 is considering treatments like finasteride and minoxidil but is hesitant due to potential side effects. Suggestions include visiting a dermatologist, using a ketoconazole shampoo, and considering that post-COVID hair loss might be an autoimmune response.

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