The Role of Mimicking Growth Factors to Control Anagen Phase: Evaluation In Vitro and In Vivo
February 2010
in “
Journal of The American Academy of Dermatology
”
mimicking growth factors anagen phase hair follicle Philpott method chronic telogen effluvium topical solution IGF EGF apoptosis dermal papilla catagen phase telogen phase diffuse hair loss hair bulb growth factors active hair growth phase hair root hair loss topical treatment insulin-like growth factor epidermal growth factor cell death hair root cells resting hair phase shedding hair phase hair thinning hair root bulb
TLDR Mimicking growth factors in a topical solution can prolong hair growth phase and reduce hair loss without side effects.
The document reports on a study that investigated the effects of mimicking growth factors (MGFs) on the hair follicle, specifically aiming to control the anagen phase, which is the active phase of hair growth. The study included an in vitro evaluation using the Philpott method and a double-blind, randomized clinical trial involving 40 women suffering from chronic telogen effluvium. The clinical trial assessed the impact of a topical solution containing MGFs (IGF 10%, EGF 10%) over an 18-month period. The results indicated that the MGF solution could prevent apoptosis in the dermal papilla, thereby prolonging the anagen phase and delaying the transition to the catagen and telogen phases. This effect was observed to reduce diffuse hair loss in patients with chronic telogen effluvium. The study concluded that the specific MGF solution had a significant effect on the hair bulb both in vitro and in vivo when used topically, and it was found to be free of side effects during the treatment period and for 12 months after the treatment ended.
