Effects of Crataegi Fructus Hot-Water Extract on Hair Growth and Growth Factor Gene Expression of Human Dermal Papilla Cells

September 2017 in “ Korean journal of acupuncture ”

Hyeong-Key Kim, Cheol Hong Kim, Hyun‐Min Yoon, Kyung‐Hwa Kang, Chun Ho Song

Crataegi Fructus hot-water extract hair growth growth factor gene expression human dermal papilla cells Minoxidil Wnt3α Wnt5α β-catenin CFWE Rogaine

TLDR Crataegi Fructus water extract may help treat hair loss.

The study investigated the effects of Crataegi Fructus hot-water extract (CFWE) on hair growth and growth factor gene expression in human dermal papilla cells (hDPCs) and C57BL/6N male mice. Mice were divided into three groups: control, CFWE-treated, and Minoxidil-treated. CFWE was applied topically twice daily for 18 days. Results showed that CFWE significantly promoted hair growth, increased hair density and thickness, and upregulated the expression of hair growth-related proteins (Wnt3α, Wnt5α, β-catenin) compared to the control group. The study concluded that CFWE could be a potential alternative treatment for hair loss.

View this study on kjacupuncture.org →

Discuss this study in the Community →

Cited in this study

5 / 5 results

research Hair Growth Activity of Crataegus Pinnatifida on C57BL/6 Mouse Model

25 citations , November 2012 in “Phytotherapy Research”

Crataegus pinnatifida extract may help increase hair growth and thickness in mice.

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations , May 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

3 / 3 results

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction, Hair Follicle Regeneration, and Wound Healing

1 citations , September 2016 in “Journal of Investigative Dermatology”

Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.

research Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

13 citations , October 2013 in “The Journal of Dermatology”

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

research Narrow-Band Red LED Light Promotes Mouse Hair Growth Through Paracrine Growth Factors From Dermal Papilla

23 citations , December 2011 in “Journal of Dermatological Science”

Red LED light helps mouse hair grow by increasing growth factors from skin cells.