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GlossaryGene Expression Regulation

control of when and how much genes produce their products

Gene Expression Regulation refers to the processes that control the timing, location, and amount of a gene's product (such as a protein) being produced. This can involve mechanisms at various stages, including transcription (when DNA is copied into RNA), RNA processing, translation (when RNA is used to make proteins), and post-translational modifications. Proper regulation is crucial for normal development, cellular function, and response to environmental changes.

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To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

research To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

23 citations, May 2016 in “American Journal of Pathology”

The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.

research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

3 citations, March 2023 in “International journal of molecular sciences”

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

research Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage

3 citations, July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 17 is important for skin's response to radiation, affecting many genes and cell division.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations, May 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

October 2021 in “Research Square (Research Square)”

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

research ATP-Dependent Chromatin Remodeling During Mammalian Development

182 citations, August 2016 in “Development”

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

research Differential Expression of KRT83 Regulated by the Transcription Factor CAP1 in Chinese Tan Sheep

5 citations, March 2017 in “Gene”

CAP1 decreases the expression of a hair-related protein in young Tan sheep's skin.

research Dynamics and Epigenetics of the Epidermal Differentiation Complex

February 2024 in “Epigenomes”

Epigenetic mechanisms control skin development by regulating gene expression.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

1308 citations, March 1998 in “Journal of bone and mineral research”

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

research A Review on Jasmonic Acid and Its Derivatives

75 citations, January 2014 in “Archiv Der Pharmazie”

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

research Hairless Is a Nuclear Receptor Corepressor Essential for Skin Function

30 citations, January 2009 in “Nuclear Receptor Signaling”

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

research Tailored Chromatin Modulation to Promote Tissue Regeneration

10 citations, May 2019 in “Seminars in Cell & Developmental Biology”

Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations, January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research Control by a Hair’s Breadth: The Role of MicroRNAs in the Skin

41 citations, September 2012 in “Cellular and Molecular Life Sciences”

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

research Epigenetics and Other Autoimmune Skin Diseases

2 citations, January 2015 in “Elsevier eBooks”

Epigenetic changes contribute to autoimmune skin diseases.

research Short-Term Responses of Soybean Roots to Individual and Combinatorial Effects of Elevated CO2 and Water Deficit

16 citations, December 2018 in “Plant Science”

Elevated CO2 can lessen the negative impact of water shortage on soybean roots and affects specific genes.

research Beneficial Effects of Zinc on Reducing Severity of Depression

2 citations, July 2019 in “Journal of psychology & clinical psychiatry”

Zinc helps reduce the severity of depression.

research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach

30 citations, December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

research Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle

7 citations, July 2008 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

24 citations, April 2020 in “Cells”

DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

June 2021 in “Research Square (Research Square)”

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

9 citations, February 2022 in “BMC Genomics”

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

9 citations, March 2018 in “International journal of molecular sciences”

Allopregnanolone changes gene expression in glioblastoma cells.

research A Comparative Study of Skin Transcriptomes and Histological Observations for Black and White Hair Colors of Giant Panda

1 citations, November 2022 in “Frontiers in medicine”

The study found that giant pandas have more melanin in black hair follicles than white, with gene expression differences that could affect hair color and skin health.