A Review on Jasmonic Acid and Its Derivatives

The document from 2014 provides a comprehensive review of jasmonic acid (JA) and its derivatives, emphasizing their significant roles in plant stress responses, development, and potential therapeutic applications. JA and its derivatives, particularly methyl jasmonate (MJ), have been shown to possess anticancer properties, inducing cell death and inhibiting cell proliferation in various cancer cell lines and patients with chronic lymphocytic leukemia. They also exhibit antidepressant, anti-aggressive, anti-inflammatory, antiparasitic, antimicrobial, and antioxidant activities. The review discusses the enhancement of secondary metabolites in plants through the exogenous application of jasmonates, which contributes to plant health and resistance. It also describes the biosynthetic pathway of jasmonates and their regulation of gene expression. Furthermore, the document covers patents related to the use of jasmonates in treating alopecia, muscle disorders, skin conditions, and improving food flavors, as well as their applications in agriculture for inducing plant resistance and improving crop quality. The conclusion highlights the significant advancements in understanding JA's biosynthesis and functions over the past 20 years, with emerging applications from novel JA derivatives and insights into their mechanisms of action.