A Review of Janus Kinase Inhibitor Use in Scarring Alopecia

    January 2025 in “ JAAD reviews. ”
    Adam Martin, Divya Sharma, Mack Y. Su … Maryanne M. Senna
    Studysummary This review discusses how JAK inhibitors, like tofacitinib and baricitinib, show promise in improving conditions like lichen planopilaris and frontal fibrosing alopecia by reducing severity scores and enhancing hair regrowth, though further research on safety and personalized approaches is needed.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. A Phase 2a Trial of Brepocitinib for Cicatricial Alopecia Journal of the American Academy of Dermatology · 2024
    2. Recalcitrant Lichen Planopilaris Treated with Upadacitinib: A Case Series International Journal of Dermatology · 2024
    3. Topical Tofacitinib for Patients with Lichen Planopilaris and/or Frontal Fibrosing Alopecia Journal of the American Academy of Dermatology · 2024
    4. Improvement of Recalcitrant Dissecting Cellulitis of the Scalp After a Trial of Upadacitinib Curēus · 2024
    5. Janus Kinase Inhibition for the Treatment of Refractory Frontal Fibrosing Alopecia: A Case Series and Review of the Literature JAAD Case Reports · 2023
    6. Hair Regrowth in a Patient With Central Centrifugal Cicatricial Alopecia After a 2-Month Trial of Baricitinib JAAD Case Reports · 2023
    7. Folliculitis Decalvans Responsive to Tofacitinib: A Case Series Dermatologic Therapy · 2020
    8. Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing British journal of dermatology/British journal of dermatology, Supplement · 2020
    9. Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series Dermatologic therapy · 2018
    10. Quality of Life and Psychosocial Impact of Scarring and Non-Scarring Alopecia in Women Journal der Deutschen Dermatologischen Gesellschaft · 2015
    11. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    12. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013

    Related research 1

    1. Erosive Pustular Dermatosis of the Scalp: Causes and Treatments International Journal of Dermatology · 2020