A Phase 2a Trial of Brepocitinib for Cicatricial Alopecia

    October 2024 in “ Journal of the American Academy of Dermatology ”
    Eden David, Neda Shokrian, Ester Del Duca … Emma Guttman‐Yassky
    Studysummary In this study, brepocitinib was found to significantly reduce inflammatory biomarker CCL5 expression and improve clinical severity by week 24, while maintaining a favorable safety profile.
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    Research cited in this study 14

    1. Hair Regrowth in a Patient With Central Centrifugal Cicatricial Alopecia After a 2-Month Trial of Baricitinib JAAD Case Reports · 2023
    2. Health-Related Quality of Life (HRQoL) Among Patients With Primary Cicatricial Alopecia (PCA): A Systematic Review Journal of the European Academy of Dermatology and Venereology · 2023
    3. Primary Cicatricial Alopecias Are Characterized by Dysregulation of Shared Gene Expression Pathways PNAS Nexus · 2022
    4. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    5. Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing British journal of dermatology/British journal of dermatology, Supplement · 2020
    6. Diffuse Variants of Scalp Lichen Planopilaris: Clinical, Trichoscopic, and Histopathologic Features of 40 Patients Journal of the American Academy of Dermatology · 2019
    7. Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series Dermatologic therapy · 2018
    8. Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections American Journal of Dermatopathology · 2014
    9. Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review Journal of the European Academy of Dermatology and Venereology · 2013
    10. Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia Archives of Dermatology · 2012
    11. Frontal Fibrosing Alopecia: A Review of 60 Cases Journal of The American Academy of Dermatology · 2012
    12. Central Scalp Alopecia Photographic Scale in African American Women Dermatologic Therapy · 2008
    13. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    14. Primary Cicatricial Alopecias: Clinicopathology of 112 Cases Journal of the American Academy of Dermatology · 2003