Brepocitinib Improves Cicatricial Alopecia and Downregulates Key T-Helper Biomarkers

July 2024 in “ Journal of Investigative Dermatology ”

Eden David, Ester Del Duca, Neda Shokrian … E. Guttman-Yassky

brepocitinib cicatricial alopecia lichen planopilaris frontal fibrosing alopecia central centrifugal cicatricial alopecia TYK2/JAK1 inhibitor Th1 Th2 Th17/IL23 T-cell activation Treg fibrosis biomarkers

Studysummary Brepocitinib improves cicatricial alopecia and reduces key immune markers.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

Read the full study on jidonline.org →

Discuss this study in the Community →

Similar research 5

A Phase 2a Trial of Brepocitinib for Cicatricial Alopecia Journal of the American Academy of Dermatology · 2024
Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology · 2021
Molecular Effect of Brepocitinib in Hidradenitis Suppurativa Journal of Investigative Dermatology · 2024
Maintenance, Withdrawal, and Re-Treatment with Ritlecitinib and Brepocitinib in Patients with Alopecia Areata in a Single-Blind Extension of a Phase 2a Randomized Clinical Trial Journal of the American Academy of Dermatology · 2021
A Phase 2a Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of the Oral Janus Kinase Inhibitors Ritlecitinib and Brepocitinib in Alopecia Areata: 24-Week Results Journal of the American Academy of Dermatology · 2021

Related Community Posts Join

6 / 1000+ results

community can someone help me identify these pls

in Treatment 10 months ago

The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 6 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 2 years ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

3 years ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.