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    Glossary TYK2 Inhibitor

    blocks enzyme activity to reduce inflammation in autoimmune diseases

    A TYK2 inhibitor is a type of medication that blocks the activity of the TYK2 enzyme, which is involved in the immune system's signaling pathways. By inhibiting this enzyme, these drugs can help reduce inflammation and are being researched for treating autoimmune diseases like psoriasis and alopecia areata.

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    Research 10 of 229

    1. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    2. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    3. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    4. 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers Journal of Investigative Dermatology · 2024
    5. JAK Family Expression and Therapeutic Implications in Primary Cicatricial Alopecias International Journal of Dermatology · 2025
    6. 802 Molecular effect of brepocitinib in hidradenitis suppurativa (HS) Journal of Investigative Dermatology · 2024
    7. A phase 2a trial of brepocitinib for cicatricial alopecia Journal of the American Academy of Dermatology · 2024 · 17 citations
    8. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    9. Tofacitinib: The selected selective JAK inhibitor in paediatric dermatology International Journal of Dermatology Venereology and Leprosy Sciences · 2024
    10. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
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