Recalcitrant Lichen Planopilaris Treated with Upadacitinib: A Case Series

    Miguel Antonio Lasheras‐Pérez, Rodolfo David Palacios‐Diaz, Conrad Pujol‐Marco, Begoña Escutia‐Muñoz, Rafael Botella‐Estrada
    Image of study
    TLDR Upadacitinib may effectively treat resistant lichen planopilaris.
    This case series explores the treatment of recalcitrant lichen planopilaris (LPP) with upadacitinib, a Janus kinase (JAK) inhibitor. The study, conducted by the Department of Dermatology at La Fe University and Polytechnic Hospital in Valencia, Spain, presents evidence that upadacitinib may be an effective treatment option for patients with LPP who have not responded to other therapies. The authors report positive outcomes in the cases treated, suggesting that JAK inhibitors could play a significant role in managing this challenging condition. No conflicts of interest or funding sources were reported.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 41 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Making the jump to hair systems

      in Hair Systems  27 upvotes 3 years ago
      19-year-old with Lichen Planopilaris tried various treatments unsuccessfully. Now considering hair systems, seeking experiences and opinions.

      community Anger and frustration as I finally learn my diagnosis.

      in Female  6 upvotes 1 year ago
      A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Clascoterone (Winlevi) Update for Canada

      in Treatment  17 upvotes 2 years ago
      Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.

    Similar Research

    5 / 1000+ results