Folliculitis Decalvans Responsive to Tofacitinib: A Case Series

July 2020 in “ Dermatologic Therapy ”

Rebekka Jerjen, Nekma Meah, Lara Trindade de Carvalho, Dmitri Wall, Rodney Sinclair

folliculitis decalvans tofacitinib Janus kinase inhibitor chronic scalp condition inflammation hair loss JAK inhibitor

TLDR Tofacitinib may effectively treat folliculitis decalvans.

The case series documented the responsiveness of folliculitis decalvans to tofacitinib treatment. The study was conducted by Rebekka Jerjen and colleagues at Sinclair Dermatology in East Melbourne, Victoria, Australia. Although the article did not provide an abstract, it highlighted the potential effectiveness of tofacitinib, a Janus kinase inhibitor, in treating this chronic scalp condition characterized by inflammation and hair loss. The findings suggested that tofacitinib could be a promising therapeutic option for patients suffering from folliculitis decalvans, offering a new avenue for managing this challenging dermatological issue.

View this study on minerva-access.unimelb.edu.au →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Successful Treatment of Refractory Folliculitis Decalvans with Secukinumab

10 citations, October 2019 in “Australasian Journal of Dermatology”

Secukinumab effectively treated a difficult case of folliculitis decalvans.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations, November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Retrospective Review of Folliculitis Decalvans in 23 Patients with Course and Treatment Analysis of Long-Standing Cases

43 citations, January 2015 in “Journal of Cutaneous Medicine and Surgery”

Most patients improved with oral antibiotics, but some needed long-term treatment or had minimal response.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations, June 2013 in “The Journal of Pathology”

Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.

research Management of Primary Cicatricial Alopecias: Options for Treatment

98 citations, May 2008 in “British Journal of Dermatology”

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

Related Community Posts Join

6 / 62 results

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 40 upvotes 1 month ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 7 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Seb derm regrowth progress? I think? Or am I just seeing what I want to see?

in Is this regrowth? 48 upvotes 11 months ago

A person with hair loss due to seborrheic dermatitis saw improvement after treating the condition and using 5mg oral minoxidil, topical minoxidil, collagen, biotin, and vitamins. They are asking if the progress is real, and others have noted the oral minoxidil as a significant treatment.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 month ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 7 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Eliminating scalp itch leads to regrowth (and my RU58841 progress)

in Research/Science 62 upvotes 1 year ago

User experienced hair regrowth after eliminating scalp itch with RU58841. Others discussed itch and hair loss connection, and effectiveness of combining RU58841 with 5AR inhibitors.

Similar Research

5 / 1000+ results

research Tumor Necrosis Factor Inhibitors and Janus Kinase Inhibitors in the Treatment of Cicatricial Alopecia: A Systematic Review

February 2024 in “PloS one”

Tofacitinib and adalimumab are promising treatments for cicatricial alopecia with few side effects.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

research Disorders of the Scalp and Hair

January 2018

Different scalp and hair disorders are more common in certain ethnic groups, with the most common being androgenetic alopecia, which is treated with medications like minoxidil and finasteride.

research Platelet-Rich Plasma in Alopecia Areata and Primary Cicatricial Alopecias: A Systematic Review

November 2022 in “Frontiers in Medicine”

PRP shows promise for treating mild alopecia areata but needs more research for cicatricial alopecias.

research Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases

May 2023 in “Journal of Clinical Medicine”

New understanding and treatments for hair loss are improving, but more research is needed.