Folliculitis Decalvans Responsive to Tofacitinib: A Case Series

July 2020 in “ Dermatologic Therapy ”

Rebekka Jerjen, Nekma Meah, Lara Trindade de Carvalho, Dmitri Wall, Rodney Sinclair

folliculitis decalvans tofacitinib Janus kinase inhibitor chronic scalp condition inflammation hair loss JAK inhibitor

Studysummary Tofacitinib may effectively treat folliculitis decalvans.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The case series documented the responsiveness of folliculitis decalvans to tofacitinib treatment. The study was conducted by Rebekka Jerjen and colleagues at Sinclair Dermatology in East Melbourne, Victoria, Australia. Although the article did not provide an abstract, it highlighted the potential effectiveness of tofacitinib, a Janus kinase inhibitor, in treating this chronic scalp condition characterized by inflammation and hair loss. The findings suggested that tofacitinib could be a promising therapeutic option for patients suffering from folliculitis decalvans, offering a new avenue for managing this challenging dermatological issue.

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Research cited in this study

6 / 6 results

research Successful Treatment of Refractory Folliculitis Decalvans with Secukinumab

10 citations , October 2019 in “Australasian Journal of Dermatology”

Secukinumab effectively treated a difficult case of folliculitis decalvans.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations , November 2016 in “Journal of The American Academy of Dermatology”

In this study, tofacitinib was reported to improve scalp hair regrowth in patients with severe alopecia areata, alopecia totalis, and alopecia universalis, showing a higher response in alopecia areata.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations , October 2015 in “Science Advances”

This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.

research Retrospective Review of Folliculitis Decalvans in 23 Patients with Course and Treatment Analysis of Long-Standing Cases

43 citations , January 2015 in “Journal of Cutaneous Medicine and Surgery”

This study found that most patients with folliculitis decalvans showed improvement and remission with oral antibiotics, although some experienced relapses and required prolonged treatment.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research Management of Primary Cicatricial Alopecias: Options for Treatment

98 citations , May 2008 in “British Journal of Dermatology”

This review discusses evidence-based guidance for managing primary cicatricial alopecias but reports no new clinical results, highlighting significant gaps in knowledge and the need for more quality trials.