TLDR CAP1 decreases the expression of a hair-related protein in young Tan sheep's skin.
The study investigated the expression of the KRT83 gene, crucial for hair development, in Chinese Tan sheep, comparing 1-month-old lambs with curly fleece to 48-month-old adults with less curly fleece. KRT83 was highly expressed in the skin of lambs but significantly reduced in adults. The core promoter region of KRT83 was identified, and CAP1 was found to bind to this region, negatively regulating KRT83 expression. Overexpression of CAP1 repressed KRT83 promoter activity, suggesting CAP1's role in the phenotypic change of fleece as the sheep age. The study provided insights into the transcriptional regulation of KRT83 and its impact on fleece characteristics.
18 citations
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June 2012 in “British Journal of Dermatology” A new mutation in the KRT86 gene causes a hair disorder with variable expression.
83 citations
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May 2011 in “Experimental Dermatology” Sheep have 17 keratin genes, similar to humans, but with different expression patterns affecting wool and hair.
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February 2010 in “Experimental Dermatology” 35 citations
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April 2022 in “Frontiers in cell and developmental biology” The research identified key proteins and genes that may influence wool bending in goats.
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November 2017 in “Asian-Australasian journal of animal sciences” Certain gene mutations are linked to wool quality in sheep and could help in breeding for better wool.
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June 2021 in “Amino acids” Human hair protein modifications could potentially indicate heart disease risk.
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January 2015 in “Experimental Dermatology” New mutations in KRT83 and KRT86 are linked to the hair disorder monilethrix.
17 citations
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May 2018 in “BMC genomics” Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.
