Love Is in the Hair: Arginine Methylation of Human Hair Proteins as Novel Cardiovascular Biomarkers

    June 2021 in “ Amino acids ”
    Alistair James Marsden, David R. Riley, Stefan T Birkett, Quentin Rodriguez-Barucg, Barbara-Ann Guinn, Sean Carroll, Lee Ingle, Thozhukat Sathyapalan, Pedro Beltrán-Álvarez
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    TLDR Human hair protein modifications could potentially indicate heart disease risk.
    This document presents a novel approach to cardiovascular disease biomarker detection by analyzing arginine methylation (ArgMe) in human hair proteins. The study identified ArgMe in hair proteins, particularly in keratin-83, using techniques such as western blot, proteomic data mining, and mass spectrometry. A preliminary cohort of 18 healthy donors showed a correlation between the levels of ArgMe in hair and serum concentrations of asymmetric dimethylarginine (ADMA), a known cardiovascular biomarker. The authors suggest that hair sampling, being cheaper, simpler, and safer than blood collection, could be a valuable non-invasive method for cardiovascular disease diagnosis and prevention if further research confirms the clinical utility of hair protein ArgMe as a biomarker.
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