Love Is in the Hair: Arginine Methylation of Human Hair Proteins as Novel Cardiovascular Biomarkers

    June 2021 in “ Amino acids ”
    Alistair James Marsden, David R. Riley, Stefan T Birkett, Quentin Rodriguez-Barucg, Barbara-Ann Guinn, Sean Carroll, Lee Ingle, Thozhukat Sathyapalan, Pedro Beltrán-Álvarez
    Image of study
    TLDR Human hair protein modifications could potentially indicate heart disease risk.
    This document presents a novel approach to cardiovascular disease biomarker detection by analyzing arginine methylation (ArgMe) in human hair proteins. The study identified ArgMe in hair proteins, particularly in keratin-83, using techniques such as western blot, proteomic data mining, and mass spectrometry. A preliminary cohort of 18 healthy donors showed a correlation between the levels of ArgMe in hair and serum concentrations of asymmetric dimethylarginine (ADMA), a known cardiovascular biomarker. The authors suggest that hair sampling, being cheaper, simpler, and safer than blood collection, could be a valuable non-invasive method for cardiovascular disease diagnosis and prevention if further research confirms the clinical utility of hair protein ArgMe as a biomarker.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 28 results

      community Small study on zinc and arginine

      in Research/Science  16 upvotes 3 years ago
      The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, and RU58841. It also touches on a study involving zinc and L-arginine.

      community Is this supplement safe? Can it raise dht?

      in Product  1 upvotes 3 months ago
      The user has been using finasteride and minoxidil since October 2023 and is concerned if a supplement containing L-arginine, L-citrulline, Tongkat Ali, Tribulus terrestris, Avena Sativa, Gingko Biloba, Ginseng, Pyridoxine, Zinc Gluconate, and Saw Palmetto can cause hair loss. They report thicker and denser hair despite ongoing shedding.

      community How to increase graft survivability after HT?

      in Transplants  6 upvotes 5 months ago
      A user is seeking advice on increasing graft survivability after a hair transplant, mentioning PRP, Mesotherapy, Stem Cell injections, and considering L-Arginine before starting Minoxidil. They are looking for ways to support blood flow before applying Minoxidil.

      community 20 to 21 how I fought hairloss for a year and my thoughts

      in Progress Pictures  18 upvotes 2 years ago
      A 21-year-old shared their one-year hair loss treatment journey, using finasteride, a multivitamin, cold water hair washes, peppermint and jojoba oil, zinc, iron, L-arginine, vitamin D, and ashwagandha. They advise seeing a doctor for finasteride, considering lifestyle changes before minoxidil, getting blood work, talking about the issue with friends, and sticking to a treatment plan for at least six months.

      community Has anyone tried KeraXL before?

      in Treatment  1 upvotes 1 year ago
      A user discussed using KeraXL serum for hair loss, which contains Biochanin-A from Red clover extract and Acetyl Tetrapeptide-3. They sought feedback on its safety and effectiveness.

    Similar Research

    5 / 688 results