TLDR Human hair protein modifications could potentially indicate heart disease risk.
This document presents a novel approach to cardiovascular disease biomarker detection by analyzing arginine methylation (ArgMe) in human hair proteins. The study identified ArgMe in hair proteins, particularly in keratin-83, using techniques such as western blot, proteomic data mining, and mass spectrometry. A preliminary cohort of 18 healthy donors showed a correlation between the levels of ArgMe in hair and serum concentrations of asymmetric dimethylarginine (ADMA), a known cardiovascular biomarker. The authors suggest that hair sampling, being cheaper, simpler, and safer than blood collection, could be a valuable non-invasive method for cardiovascular disease diagnosis and prevention if further research confirms the clinical utility of hair protein ArgMe as a biomarker.
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January 2018 in “Scientific reports” Human hair contains diverse proteins, including keratins and histones, which could help assess hair health and aging.
[object Object] 14 citations,
September 2017 in “Proteomics. Clinical applications” Hair protein analysis could improve medical testing and understanding of hair characteristics.
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March 2017 in “Gene” CAP1 decreases the expression of a hair-related protein in young Tan sheep's skin.
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July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
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March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
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November 2015 in “Indian Journal of Clinical Biochemistry” The conference presented findings on how vitamin D levels, genetic factors, and lifestyle choices like smoking and yoga affect various health conditions and diseases.
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October 2021 in “Frontiers in Endocrinology” Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.
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July 2016 in “Genetica” BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.
