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TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

Targeting Vδ1+T-cells may help treat alopecia areata.

Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Both treatments for alopecia areata are equally effective and safe.

Heat treatment increases hair loss in certain mice.

Activating Nrf2 can help protect against hearing loss.

Scaffoldin helps form hard skin structures in chicken embryos.

Medium-dose prednisolone pulse therapy is effective and safe for multifocal alopecia areata but not for more severe forms.

Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.

Activin A and follistatin control when hair cells develop in mouse ears.

Topical immunotherapy is the best treatment for severe alopecia areata.

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

Alopecia areata patients, especially women with nail issues or atopic diseases, are at higher risk for other autoimmune diseases.

Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.

A protein found in safflower seeds can stimulate hair growth and speed up wound healing in mice.

Testosterone helps prevent skin damage in males by acting through both estrogen and androgen pathways.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.

Human skin can be reconnected to nerves using stem cells, which may help with skin health and healing.

New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.

Wharton's jelly-derived stem cells were safely used to treat four alopecia patients, resulting in hair regrowth in all of them.

Biotin is important for keeping zinc levels balanced in the skin and its lack can cause hair loss.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.

Inhibiting Zyxin may help treat androgenetic alopecia by promoting hair growth.