Immunolocalization of Scaffoldin, a Trichohyalin-Like Protein, in the Epidermis of the Chicken Embryo

    August 2014 in “ The Anatomical Record
    Lorenzo Alibardi, Veronika Mlitz, Leopold Eckhart
    TLDR Scaffoldin helps form hard skin structures in chicken embryos.
    The study investigated the localization of scaffoldin, a trichohyalin-like protein, in the embryonic epidermis of chicken, finding it predominantly in periderm granules of claws, skin, lingual papillae, and feather sheaths. Immunohistochemical and ultrastructural analyses confirmed scaffoldin's role in the cornification process. Scaffoldin and corneous beta-proteins were found to be synthesized in temporary tissues, supporting epidermal development and the formation of hard skin appendages. The study highlighted the variable stratification of the embryonic epidermis and linked the disappearance of periderm granules to the increased production of corneous beta-proteins, which replace softer cells with hard corneocytes.
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